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Details on Person UniProt:Q96AQ7-1 CIDEC
| Class:Id | ReferenceIsoform:412642 |
|---|---|
| _chainChangeLog | chain:1-238 added on Sat February 7 2015 |
| _displayName | UniProt:Q96AQ7-1 CIDEC |
| _timestamp | 2024-11-03 20:09:20 |
| chain | chain:1-238 |
| checksum | 5CF774929E821DA5 |
| comment | FUNCTION Lipid transferase specifically expressed in white adipose tissue, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion (PubMed:18334488, PubMed:19843876, PubMed:20049731, PubMed:23399566, PubMed:30361435). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (PubMed:18334488, PubMed:19843876, PubMed:20049731, PubMed:23399566). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by undergoing liquid-liquid phase separation (LLPS) and promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (PubMed:18334488, PubMed:19843876, PubMed:20049731, PubMed:23399566). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair (PubMed:18334488, PubMed:19843876, PubMed:20049731, PubMed:23399566). Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1 (PubMed:23399566). May also act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH (By similarity). When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment (PubMed:12429024).CATALYTIC ACTIVITY a triacyl-sn-glycerol(in) = a triacyl-sn-glycerol(out)SUBUNIT Homodimer (By similarity). Homooligomer; undergoes liquid-liquid phase separation (LLPS) via its N-terminus, facilitating lipid droplet fusion, occurs at the lipid droplet contact sites (By similarity). Interacts with CIDEA (PubMed:19843876). Interacts with PLIN1 (PubMed:23399566). Interacts with NFAT5; this interaction is direct and retains NFAT5 in the cytoplasm (By similarity). Interacts with CEBPB (By similarity). Interacts with isoform CLSTN3beta of CLSTN3; inhibiting the lipid transferase activity of CIDEC (By similarity).INTERACTION Diffuses quickly on lipid droplet surface, but becomes trapped and clustered at lipid droplet contact sites, thereby enabling its rapid enrichment at lipid droplet contact sites.ALTERNATIVE PRODUCTS Expressed mainly in adipose tissue, small intestine, heart, colon and stomach and, at lower levels, in brain, kidney and liver.DOMAIN The CIDE-N domain is involved in homodimerization which is crucial for its function in promoting lipid exchange and transfer.PTM Ubiquitinated and targeted to proteasomal degradation, resulting in a short half-life (about 15 minutes in 3T3-L1 cells). Protein stability depends on triaclyglycerol synthesis, fatty acid availability and lipid droplet formation.DISEASE In omental adipose tissue of obese patients matched for BMI, expression levels tend to correlate with insulin sensitivity. Expression is increased 2-3 fold in the group of patients with high insulin sensitivity, compared to the insulin-resistant group. This observation is consistent with the idea that triglyceride storage in adipocytes plays an important role in sequestering triglycerides and fatty acids away from the circulation and peripheral tissues, thus enhancing insulin sensitivity in liver and muscle. This effect is not significant in subcutaneous adipose tissue (PubMed:18509062). In subcutaneous adipose tissue of diabetic patients, tends to negatively correlate with body mass index and total fat mass, independently of insulin sensitivity (PubMed:18334488).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the CIDE family. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: fullName evidence="17"Lipid transferase CIDEC alternativeName: fullName evidence="11"Cell death activator CIDE-3 alternativeName: fullName evidence="17"Cell death-inducing DFFA-like effector protein C alternativeName: fullName evidence="14"Fat-specific protein FSP27 homolog |
| geneName | CIDEC FSP27 |
| identifier | Q96AQ7 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Activator Alternative splicing Apoptosis Endoplasmic reticulum Lipid droplet Lipid transport Nucleus Proteomics identification Reference proteome Transcription Transcription regulation Transport Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CIDEC |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:6784638] ENSEMBL:ENSG00000187288 CIDEC [Homo sapiens] |
| secondaryIdentifier | CIDEC_HUMAN C9JMN7 Q67DW9 Q9GZY9 |
| sequenceLength | 238 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q96AQ7-1 |
| (referenceEntity) | [EntityWithAccessionedSequence:6784693] CIDEC [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q96AQ7-1 CIDEC (412642)
