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Details on Person UniProt:Q969S8 HDAC10
| Class:Id | ReferenceGeneProduct:412605 |
|---|---|
| _chainChangeLog | chain:1-669 added on Sat February 7 2015 |
| _displayName | UniProt:Q969S8 HDAC10 |
| _timestamp | 2025-02-21 19:07:27 |
| chain | chain:1-669 |
| checksum | 872D9427E6893A18 |
| comment | FUNCTION Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11677242, PubMed:11726666, PubMed:11739383, PubMed:11861901). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039).CATALYTIC ACTIVITY N(8)-acetylspermidine + H2O = spermidine + acetateCATALYTIC ACTIVITY N-acetylputrescine + H2O = putrescine + acetateCATALYTIC ACTIVITY N-acetylcadaverine + H2O = cadaverine + acetateCATALYTIC ACTIVITY N(6)-acetyl-L-lysyl-[protein] + H2O = L-lysyl-[protein] + acetateBIOPHYSICOCHEMICAL PROPERTIES Interacts with HDAC3 (PubMed:11861901). Interacts with HDAC2 and NCOR2/SMRT (PubMed:11739383). Interacts with HSPA8/HSC70 (PubMed:23801752). Interacts with MSH2 (PubMed:26221039).INTERACTION Excluded from nucleoli.ALTERNATIVE PRODUCTS Widely expressed with high levels in liver and kidney.DISEASE In neuroblastoma cells, may promote autophagy in response to chemotherapy-induced DNA damage and efflux of chemotherapeutics via lysosomal exocytosis, hence protecting cells from cytotoxic agents (PubMed:23801752, PubMed:29968769). Expression levels may correlate with survival in neuroblastoma patients, with low levels in the tumor correlating with long-term patient survival and high expression with poor prognosis (PubMed:23801752). Therefore has been proposed as a biomarker to predict neuroblastoma chemoresistance and treatment outcome (PubMed:23801752).MISCELLANEOUS Like some other members of the HD type 2 subfamily, such as HDAC4, inhibited by the antitumor drug trichostatin A (TSA).MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.SIMILARITY Belongs to the histone deacetylase family. HD type 2 subfamily.CAUTION Protein/histone deacetylase activity in vivo is uncertain. The 3D structure analysis of the zebrafish ortholog shows that a glutamate gatekeeper and a sterically constricted active site confer specificity for N(8)-acetylspermidine hydrolysis and disfavour acetyllysine hydrolysis. Supporting this observation, has been shown to exhibit only very low activity, if any, towards acetyl-lysine peptide substrates (PubMed:28516954). However, histone deacetylase activity has been observed in vitro (PubMed:11677242, PubMed:11726666, PubMed:11739383, PubMed:11861901, PubMed:28516954). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Polyamine deacetylase HDAC10 ecNumber evidence="10"3.5.1.48 ecNumber evidence="10"3.5.1.62 alternativeName: Histone deacetylase 10 shortName: HD10 |
| geneName | HDAC10 |
| identifier | Q969S8 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Autophagy Cytoplasm DNA damage DNA recombination DNA repair Hydrolase Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | HDAC10 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998347] ENSEMBL:ENSG00000100429 HDAC10 [Homo sapiens] |
| secondaryIdentifier | HDA10_HUMAN Q08AP4 Q6STF9 Q96P77 Q96P78 Q9H028 Q9UGX1 Q9UGX2 |
| sequenceLength | 669 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:56404] UniProt:Q969S8-1 HDAC10 [Homo sapiens] [ReferenceIsoform:148320] UniProt:Q969S8-2 HDAC10 [Homo sapiens] [ReferenceIsoform:148322] UniProt:Q969S8-4 HDAC10 [Homo sapiens] [ReferenceIsoform:231581] UniProt:Q969S8-5 HDAC10 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:351579] HDAC10 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q969S8 HDAC10 (412605)
