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Details on Person UniProt:Q93008-1 USP9X
| Class:Id | ReferenceIsoform:412531 |
|---|---|
| _chainChangeLog | chain:1-2570 added on Fri February 6 2015;chain:1-2570 for 412531 removed on Thu November 5 2020;chain:1-2554 for 412531 added on Thu November 5 2020 |
| _displayName | UniProt:Q93008-1 USP9X |
| _timestamp | 2024-11-03 20:17:21 |
| chain | chain:1-2554 |
| checksum | 16B87B7FCC1428AF |
| comment | FUNCTION Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (PubMed:18254724, PubMed:19135894, PubMed:22371489, PubMed:25944111, PubMed:29626158, PubMed:30914461, PubMed:37454738). May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin (PubMed:18254724, PubMed:19135894, PubMed:22371489, PubMed:25944111, PubMed:29626158, PubMed:30914461, PubMed:37454738). Specifically hydrolyzes 'Lys-11'-, followed by 'Lys-63'-, 'Lys-48'- and 'Lys-6'-linked polyubiquitins chains (PubMed:30914461). Essential component of TGF-beta/BMP signaling cascade (PubMed:19135894). Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33 (PubMed:19135894). Deubiquitinates alkylation repair enzyme ALKBH3 (PubMed:25944111). OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Deubiquitinates RNA demethylase enzyme ALKBH5, promoting its stability (PubMed:37454738). Deubiquitinates mTORC2 complex component RICTOR at 'Lys-294' by removing 'Lys-63'-linked polyubiquitin chains, stabilizing RICTOR and enhancing its binding to MTOR, thus promoting mTORC2 complex assembly (PubMed:33378666). Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres (PubMed:16322459). Involved in axonal growth and neuronal cell migration (PubMed:24607389). Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein BMAL1 via its deubiquitinating activity (PubMed:29626158). Acts as a regulator of peroxisome import by mediating deubiquitination of PEX5: specifically deubiquitinates PEX5 monoubiquitinated at 'Cys-11' following its retrotranslocation into the cytosol, resetting PEX5 for a subsequent import cycle (PubMed:22371489). Deubiquitinates PEG10 (By similarity). Inhibits the activation of the Hippo signaling pathway via deubiquitination of AMOTL2 at 'Lys-347' and 'Lys-408' which prohibits its interaction with and activation of LATS2. Loss of LATS2 activation and subsequent loss of YAP1 phosphorylation results in an increase in YAP1-driven transcription of target genes (PubMed:26598551, PubMed:34404733).CATALYTIC ACTIVITY Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).SUBUNIT Interacts with SMAD4, MARK4, NUAK1 and BIRC5/survivin (PubMed:16322459, PubMed:18254724, PubMed:19135894). Interacts with DCX (PubMed:24607389). Interacts with OTUD4 and USP7; the interaction is direct (PubMed:25944111).INTERACTION Widely expressed in embryonic and adult tissues.INDUCTION By growth factors.DISEASE The disease may be caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Escapes X-inactivation.SIMILARITY Belongs to the peptidase C19 family. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Ubiquitin carboxyl-terminal hydrolase 9X ecNumber evidence="7 8 11 12 14 15 18"3.4.19.12 alternativeName: Deubiquitinating enzyme FAF-X alternativeName: Fat facets in mammals shortName: hFAM alternativeName: Fat facets protein-related, X-linked alternativeName: Ubiquitin thioesterase FAF-X alternativeName: Ubiquitin-specific protease 9, X chromosome alternativeName: Ubiquitin-specific-processing protease FAF-X |
| geneName | USP9X DFFRX FAM USP9 |
| identifier | Q93008 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Biological rhythms Cell cycle Cell division Cell projection Chromosome partition Cytoplasm Cytoskeleton Disease variant Hydrolase Intellectual disability Mitosis Phosphoprotein Protease Proteomics identification Reference proteome Thiol protease Ubl conjugation pathway Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | USP9X |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8960200] ENSEMBL:ENSG00000124486 USP9X [Homo sapiens] |
| secondaryIdentifier | USP9X_HUMAN O75550 Q8WWT3 Q8WX12 |
| sequenceLength | 2554 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q93008-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q93008-1 USP9X (412531)
