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Details on Person UniProt:Q92804 TAF15
| Class:Id | ReferenceGeneProduct:412494 |
|---|---|
| _chainChangeLog | chain:1-592 added on Fri February 6 2015 |
| _displayName | UniProt:Q92804 TAF15 |
| _timestamp | 2025-08-15 21:48:23 |
| chain | chain:1-592 |
| checksum | 73D37C171E1E2BCA |
| comment | FUNCTION RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Can enter the preinitiation complex together with the RNA polymerase II (Pol II).SUBUNIT Belongs to the RNA polymerase II (Pol II) transcriptional multiprotein complex, together with the TATA-binding protein (TBP) and other TBP-associated factors (TAF(II)s). Binds SF1.INTERACTION Shuttles from the nucleus to the cytoplasm.ALTERNATIVE PRODUCTS Ubiquitous. Observed in all fetal and adult tissues.PTM Dimethylated by PRMT1 at Arg-206 to asymmetric dimethylarginine. The methylation may favor nuclear localization and positive regulation of TAF15 transcriptional activity.PTM ADP-ribosylated during genotoxic stress.DISEASE A chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with NR4A3.SIMILARITY Belongs to the RRM TET family. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: TATA-binding protein-associated factor 2N alternativeName: 68 kDa TATA-binding protein-associated factor shortName: TAF(II)68 shortName: TAFII68 alternativeName: RNA-binding protein 56 |
| geneName | TAF15 RBP56 TAF2N |
| identifier | Q92804 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation ADP-ribosylation Alternative splicing Chromosomal rearrangement Cytoplasm Direct protein sequencing DNA-binding Isopeptide bond Metal-binding Methylation Nucleus Phosphoprotein Proteomics identification Proto-oncogene Reference proteome Repeat RNA-binding Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6791590] Weiser, JD [InstanceEdit:8856987] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | TAF15 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002580] ENSEMBL:ENSG00000270647 TAF15 [Homo sapiens] |
| secondaryIdentifier | RBP56_HUMAN B2R837 Q86X94 Q92751 |
| sequenceLength | 592 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:62804] UniProt:Q92804-1 TAF15 [Homo sapiens] [ReferenceIsoform:152779] UniProt:Q92804-2 TAF15 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9020680] TAF15 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q92804 TAF15 (412494)
