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Details on Person UniProt:Q92608-1 DOCK2
| Class:Id | ReferenceIsoform:412468 |
|---|---|
| _chainChangeLog | chain:1-1830 added on Fri February 6 2015 |
| _displayName | UniProt:Q92608-1 DOCK2 |
| _timestamp | 2024-11-03 19:45:29 |
| chain | chain:1-1830 |
| checksum | 18568D3322DAA92A |
| comment | FUNCTION Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.SUBUNIT Homodimer (Probable). Interacts with RAC1 and RAC2. Interacts with CRKL and VAV. Interacts with CD3Z.INTERACTION Colocalizes with F-actin.ALTERNATIVE PRODUCTS Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon.DOMAIN The DOCKER domain may mediate the GEF activity.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Splicing donor and acceptor sites between exon 6 and exon 7 are not canonical.SIMILARITY Belongs to the DOCK family.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Dedicator of cytokinesis protein 2 |
| geneName | DOCK2 KIAA0209 |
| identifier | Q92608 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cytoplasm Cytoskeleton Disease variant Guanine-nucleotide releasing factor Membrane Phosphoprotein Proteomics identification Reference proteome SH3 domain |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | DOCK2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990654] ENSEMBL:ENSG00000134516 DOCK2 [Homo sapiens] |
| secondaryIdentifier | DOCK2_HUMAN Q2M3I0 Q96AK7 |
| sequenceLength | 1830 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q92608-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q92608-1 DOCK2 (412468)
