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Details on Person UniProt:Q924K8-1 Mta3
| Class:Id | ReferenceIsoform:412424 |
|---|---|
| _chainChangeLog | chain:1-591 added on Fri February 6 2015 |
| _displayName | UniProt:Q924K8-1 Mta3 |
| _timestamp | 2025-08-15 21:46:53 |
| chain | chain:1-591 |
| checksum | ABA5CB9E86FCE7E2 |
| comment | FUNCTION Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.SUBUNIT Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5. The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes. Interacts with BCL6. Interacts with NACC2 (By similarity). Interacts with PWWP2B (PubMed:34180153).SUBCELLULAR LOCATION Expressed in heart, brain, spleen, lung, liver and kidney.SIMILARITY Belongs to the metastasis-associated protein family. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Metastasis-associated protein MTA3 |
| geneName | Mta3 |
| identifier | Q924K8 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm DNA-binding Metal-binding Nucleus Phosphoprotein Reference proteome Zinc Zinc-finger |
| modified | [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Mta3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | MTA3_MOUSE Q8VC18 |
| sequenceLength | 591 |
| species | [Species:48892] Mus musculus |
| variantIdentifier | Q924K8-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q924K8-1 Mta3 (412424)
