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Details on Person UniProt:Q8WWV6-1 FCAMR
| Class:Id | ReferenceIsoform:412144 |
|---|---|
| _chainChangeLog | signal peptide:1-16 added on Sat February 7 2015;chain:17-532 added on Sat February 7 2015 |
| _displayName | UniProt:Q8WWV6-1 FCAMR |
| _timestamp | 2025-02-21 19:47:52 |
| chain | signal peptide:1-16 chain:17-532 |
| checksum | D347A23C0F41EED3 |
| comment | FUNCTION Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM.SUBUNIT Interacts with IGHM; this interaction facilitates the endocytosis of IgM-coated microbes or IgM-antigen immune complexes.SUBCELLULAR LOCATION Expressed by mesangial cells.INDUCTION Up-regulated by IFNG/IFN-gamma in mesangial cells.PTM N-glycosylated.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: fullName evidence="9"High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor alternativeName: Fc alpha/mu receptor cdAntigenNameCD351/cdAntigenName |
| geneName | FCAMR FKSG87 |
| identifier | Q8WWV6 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Adaptive immunity Alternative splicing Cell membrane Disulfide bond Glycoprotein Immunity Immunoglobulin domain Membrane Proteomics identification Receptor Reference proteome Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | FCAMR |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992451] ENSEMBL:ENSG00000162897 FCAMR [Homo sapiens] |
| secondaryIdentifier | FCAMR_HUMAN A0A0B4J1S2 Q32M82 Q8WWV5 Q96SA2 |
| sequenceLength | 532 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q8WWV6-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8WWV6-1 FCAMR (412144)
