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Details on Person UniProt:Q8WVD3-1 RNF138
| Class:Id | ReferenceIsoform:412112 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-245 added on Sat February 7 2015;initiator methionine:1 for 412112 removed on Fri Nov 03 2023;initiator methionine: for 412112 added on Fri Nov 03 2023;initiator methionine: for 412112 removed on Fri Aug 15 2025;initiator methionine:1 for 412112 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q8WVD3-1 RNF138 |
| _timestamp | 2025-08-15 21:18:28 |
| chain | initiator methionine:1 chain:2-245 |
| checksum | 807EE4500BE0919C |
| comment | FUNCTION E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285). Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285). May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285).CATALYTIC ACTIVITY S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Interacts with NLK (PubMed:16714285). Interacts with XRCC5/Ku80 (PubMed:26502055). Interacts with RBBP8/CtIP (PubMed:26502057).INTERACTION Recruited at DNA damage sites (PubMed:26502055). Localizes to sites of double-strand break: localization to double-strand break sites is mediated by the zinc fingers (PubMed:26502055, PubMed:26502057).ALTERNATIVE PRODUCTS The zinc finger domains (C2H2-type and C2HC-type zinc fingers) bind DNA and mediate recruitment to double-strand break sites. They show strong preference for DNA with 5'- or 3'-single-stranded overhangs, while they do not bind blunt-ended double-stranded DNA or poly(ADP-ribose) (PAR) polymers.PTM Auto-ubiquitinated. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: fullName evidence="10"E3 ubiquitin-protein ligase RNF138 ecNumber evidence="10"2.3.2.27 alternativeName: fullName evidence="9"Nemo-like kinase-associated RING finger protein shortName evidence="9"NLK-associated RING finger protein shortName evidence="9"hNARF alternativeName: fullName evidence="10"RING finger protein 138 alternativeName: fullName evidence="10"RING-type E3 ubiquitin transferase RNF138 |
| geneName | RNF138 NARF HSD-4 HSD4 |
| identifier | Q8WVD3 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing Chromosome DNA damage DNA repair DNA-binding Metal-binding Phosphoprotein Proteomics identification Reference proteome Repeat Transferase Ubl conjugation Ubl conjugation pathway Wnt signaling pathway Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | RNF138 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003781] ENSEMBL:ENSG00000134758 RNF138 [Homo sapiens] |
| secondaryIdentifier | RN138_HUMAN B2RE17 Q9H8K2 Q9UF87 Q9UKI6 |
| sequenceLength | 245 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q8WVD3-1 |
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No pathways have been reviewed or authored by UniProt:Q8WVD3-1 RNF138 (412112)
