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Details on Person UniProt:Q8TAD4 SLC30A5
| Class:Id | ReferenceGeneProduct:411790 |
|---|---|
| _chainChangeLog | chain:1-765 added on Fri February 6 2015 |
| _displayName | UniProt:Q8TAD4 SLC30A5 |
| _timestamp | 2025-02-21 19:14:47 |
| chain | chain:1-765 |
| checksum | CD96BB6D710DF42D |
| comment | FUNCTION Together with SLC30A6 forms a functional proton-coupled zinc ion antiporter mediating zinc entry into the lumen of organelles along the secretory pathway (PubMed:11904301, PubMed:15525635, PubMed:15994300, PubMed:19366695, PubMed:22529353). By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis (PubMed:15525635, PubMed:15994300, PubMed:16636052, PubMed:35525268). Through the transport of zinc into secretory granules of pancreatic beta-cells, plays an important role in the storage and secretion of insulin (PubMed:11904301).FUNCTION Zinc ion:proton antiporter mediating influx and efflux of zinc at the plasma membrane.CATALYTIC ACTIVITY Zn(2+)(in) + 2 H(+)(out) = Zn(2+)(out) + 2 H(+)(in)CATALYTIC ACTIVITY Zn(2+)(in) + 2 H(+)(out) = Zn(2+)(out) + 2 H(+)(in)BIOPHYSICOCHEMICAL PROPERTIES Heterodimer with SLC30A6/ZNT6; form a functional zinc ion transmembrane transporter.INTERACTION Enriched in early compartments of the secretory pathway including COPII-coated vesicles and the Golgi cis cisterna.SUBCELLULAR LOCATION Ubiquitously expressed (PubMed:11904301, PubMed:12095919). Highly expressed in pancreas, liver and kidney (PubMed:11904301). Expressed abundantly in insulin-containing beta cells, undetectable in other endocrine cell types including glucagon-secreting alpha cells and most acinar cells (at protein level) (PubMed:11904301).INDUCTION Expression is regulated by zinc (PubMed:11937503, PubMed:15276077, PubMed:25582195). Up-regulated by endoplasmic reticulum stress (PubMed:16636052).PTM Could homodimerize through the formation of dityrosine bonds upon oxidative stress.SIMILARITY Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: fullName evidence="24"Proton-coupled zinc antiporter SLC30A5 alternativeName: fullName evidence="28"Solute carrier family 30 member 5 alternativeName: fullName evidence="19"Zinc transporter 5 shortName evidence="19"ZnT-5 alternativeName: fullName evidence="20"ZnT-like transporter 1 shortName evidence="20"hZTL1 |
| geneName | SLC30A5 ZNT5 ZNTL1 ZTL1 UNQ863/PRO1879 |
| identifier | Q8TAD4 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing Antiport Cell membrane Cytoplasmic vesicle Endoplasmic reticulum Golgi apparatus Ion transport Membrane Metal-binding Proteomics identification Reference proteome Transmembrane Transmembrane helix Transport Zinc Zinc transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | SLC30A5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000992] ENSEMBL:ENSG00000145740 SLC30A5 [Homo sapiens] |
| secondaryIdentifier | ZNT5_HUMAN B7ZM89 Q6UX54 Q7L4M4 Q8TDG3 Q9BVY8 Q9H9H1 |
| sequenceLength | 765 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:258039] UniProt:Q8TAD4-1 SLC30A5 [Homo sapiens] [ReferenceIsoform:258040] UniProt:Q8TAD4-2 SLC30A5 [Homo sapiens] [ReferenceIsoform:8973608] UniProt:Q8TAD4-3 SLC30A5 [Homo sapiens] [ReferenceIsoform:8973609] UniProt:Q8TAD4-4 SLC30A5 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:437105] SLC30A5 [secretory granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:9817559] SLC30A5 [Golgi membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q8TAD4 SLC30A5 (411790)
