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Details on Person UniProt:Q8N9B5-1 JMY
| Class:Id | ReferenceIsoform:411399 |
|---|---|
| _chainChangeLog | chain:1-988 added on Sat February 7 2015 |
| _displayName | UniProt:Q8N9B5-1 JMY |
| _timestamp | 2024-11-03 20:19:38 |
| chain | chain:1-988 |
| checksum | 7166FF8AE325F37A |
| comment | FUNCTION Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions (PubMed:30420355). In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments (PubMed:30420355). Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments (PubMed:30420355). Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy (PubMed:30420355). The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity).SUBUNIT Interacts with p300/EP300, the complex activates p53/TP53 transcriptional activity. Interacts with TTC5; the interaction facilitates the association between JMY and p300/EP300 (By similarity). Interacts with MAP1LC3B; the interaction results in the activation of JYM's nucleation activity in the cytoplasm (PubMed:30420355). Interacts with TTC5/STRAP; the interaction results in the inhibition of JYM's nucleation activity in the cytoplasm due to competition with MAP1LC3B binding (PubMed:30420355).INTERACTION Localizes to the nucleus in most cell types. Accumulates in nucleus under DNA damage conditions, increasing p53/TP53 transcription response and reducing its influence on cell motility (By similarity). In primary neutrophils, it colocalizes with actin filaments at the leading edge and is excluded from the nucleus. Localization correlates with motility, because it moves from the nucleus to the cytoplasmic compartment when cells are differentiated from nonmotile cells into highly motile neutrophil-like cells. Localizes to cytoplasmic vesicles which associate with actin filament and autophagosomal membranes upon starvation-induced autophagy (PubMed:30420355).ALTERNATIVE PRODUCTS By E2F.DOMAIN The N-terminal region is involved in actin binding and actin nucleation activity.PTM Ubiquitinated by MDM2, leading to its subsequent degradation by the proteasome. In case of DNA damage, the interaction with MDM2 is altered, preventing degradation and allowing interaction with p300/EP300 and its function in p53/TP53 stress response (By similarity).SIMILARITY Belongs to the JMY family. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Junction-mediating and -regulatory protein |
| geneName | JMY |
| identifier | Q8N9B5 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Actin-binding Alternative splicing Coiled coil Cytoplasm Cytoplasmic vesicle Cytoskeleton DNA damage DNA repair Lipoprotein Membrane Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | JMY |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993692] ENSEMBL:ENSG00000152409 JMY [Homo sapiens] |
| secondaryIdentifier | JMY_HUMAN A1L4P5 B5MDS2 B5MDT0 |
| sequenceLength | 988 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q8N9B5-1 |
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No pathways have been reviewed or authored by UniProt:Q8N9B5-1 JMY (411399)
