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Details on Person UniProt:Q8IZK6-1 MCOLN2
| Class:Id | ReferenceIsoform:410974 |
|---|---|
| _chainChangeLog | chain:1-566 added on Fri February 6 2015 |
| _displayName | UniProt:Q8IZK6-1 MCOLN2 |
| _timestamp | 2024-11-03 20:20:03 |
| chain | chain:1-566 |
| checksum | 6F017BA416624E63 |
| comment | FUNCTION Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:19885840, PubMed:19940139). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (PubMed:17662026). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). Also functions as a Fe(2+) permeable channel (By similarity).CATALYTIC ACTIVITY Ca(2+)(in) = Ca(2+)(out)CATALYTIC ACTIVITY Fe(2+)(in) = Fe(2+)(out)ACTIVITY REGULATION Channel activity is reduced by low extracellular/lumenal pH level (PubMed:19940139).SUBUNIT Forms homooligomeric complexes; probably tetrameric (By similarity). Can heterooligomerize with MCOLN1; heteromeric assemblies have different channel properties as compared to the respective homooligomers and may be tissue-specific (PubMed:19885840). Interacts with TMEM176A (PubMed:25130899).SUBCELLULAR LOCATION Localizes to recycling endosomes in activated macrophages and microglia.ALTERNATIVE PRODUCTS The most N-terminal extracellular/lumenal domain (referred to as I-II linker or polycystin-mucolipin domain) contributes to a structure with a four-fold rotational symmetry in a tetrameric assembly; the structure contains a central highly electronegative pore with a 14 A diameter. The pore is critical for Ca(2+) and pH regulation. The protruding structure formed by the I-II linkers may contain all the interaction sites with lipids and proteins in the endolysosomal lumen.SIMILARITY Belongs to the transient receptor (TC 1.A.4) family. Polycystin subfamily. MCOLN2 sub-subfamily.SEQUENCE CAUTION Truncated C-terminus. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Mucolipin-2 alternativeName: Transient receptor potential channel mucolipin 2 shortName: TRPML2 |
| geneName | MCOLN2 |
| identifier | Q8IZK6 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Adaptive immunity Alternative splicing Calcium Calcium channel Calcium transport Cell membrane Disulfide bond Endosome Immunity Innate immunity Ion channel Ion transport Lysosome Membrane Protein transport Proteomics identification Reference proteome Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | MCOLN2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991969] ENSEMBL:ENSG00000153898 MCOLN2 [Homo sapiens] |
| secondaryIdentifier | MCLN2_HUMAN A6NI99 Q2M3I6 Q5TAG5 Q8N9R3 |
| sequenceLength | 566 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q8IZK6-1 |
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No pathways have been reviewed or authored by UniProt:Q8IZK6-1 MCOLN2 (410974)
