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Details on Person UniProt:Q8IXI1 RHOT2
| Class:Id | ReferenceGeneProduct:410886 |
|---|---|
| _chainChangeLog | chain:1-618 added on Sat February 7 2015 |
| _displayName | UniProt:Q8IXI1 RHOT2 |
| _timestamp | 2025-08-15 22:01:55 |
| chain | chain:1-618 |
| checksum | C72ECBCA33D04B6B |
| comment | FUNCTION Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking (PubMed:16630562, PubMed:22396657, PubMed:30513825). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:22396657). Can hydrolyze GTP (By similarity). Can hydrolyze ATP and UTP (PubMed:30513825).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)CATALYTIC ACTIVITY ATP + H2O = ADP + phosphate + H(+)CATALYTIC ACTIVITY UTP + H2O = UDP + phosphate + H(+)SUBUNIT Homodimer (PubMed:27605430). Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules (PubMed:16630562). Interacts with ARMCX3 (By similarity). Found in a complex with KIF5B, OGT, RHOT1 and TRAK1 (PubMed:24995978).INTERACTION Colocalizes with MGARP and RHOT2 at the mitochondria.ALTERNATIVE PRODUCTS Ubiquitously expressed. Highly expressed in heart, liver, skeletal muscle, kidney and pancreas.DOMAIN The Miro 2 domain is necessary for efficient ubiquitination by PRKN.PTM Ubiquitinated by PRKN in a PINK1-dependent manner, leading to its degradation.SIMILARITY Belongs to the mitochondrial Rho GTPase family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Mitochondrial Rho GTPase 2 shortName: MIRO-2 shortName: hMiro-2 ecNumber evidence="1"3.6.5.- alternativeName: Ras homolog gene family member T2 |
| geneName | RHOT2 ARHT2 C16orf39 |
| identifier | Q8IXI1 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Calcium GTP-binding Hydrolase Isopeptide bond Magnesium Membrane Metal-binding Mitochondrion Mitochondrion outer membrane Nucleotide-binding Proteomics identification Reference proteome Repeat Transmembrane Transmembrane helix Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | RHOT2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000695] ENSEMBL:ENSG00000140983 RHOT2 [Homo sapiens] |
| secondaryIdentifier | MIRO2_HUMAN A2IDC2 Q8NF53 Q96C13 Q96S17 Q9BT60 Q9H7M8 |
| sequenceLength | 618 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:194860] UniProt:Q8IXI1-2 RHOT2 [Homo sapiens] [ReferenceIsoform:194903] UniProt:Q8IXI1-1 RHOT2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:3006729] RHOT2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:3006730] RHOT2 [mitochondrial outer membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q8IXI1 RHOT2 (410886)
