Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q8IV63-1 VRK3
| Class:Id | ReferenceIsoform:410802 |
|---|---|
| _chainChangeLog | chain:1-474 added on Sat February 7 2015 |
| _displayName | UniProt:Q8IV63-1 VRK3 |
| _timestamp | 2025-02-21 19:44:48 |
| chain | chain:1-474 |
| checksum | 86B9B91050A7F0CC |
| comment | FUNCTION Plays a role in the regulation of the cell cycle by phosphorylating the nuclear envelope protein barrier-to-autointegration factor/BAF that is required for disassembly and reassembly, respectively, of the nuclear envelope during mitosis (PubMed:25899223). Under normal physiological conditions, negatively regulates ERK activity along with VHR/DUSP3 phosphatase in the nucleus, causing timely and transient action of ERK. Stress conditions activate CDK5 which phosphorylates VRK3 to increase VHR phosphatase activity and suppress prolonged ERK activation that causes cell death (PubMed:27346674). For example, upon glutamate induction, promotes nuclear localization of HSP70/HSPA1A to inhibit ERK activation via VHR/DUSP3 phosphatase (PubMed:27941812).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)SUBUNIT Interacts with DUSP3 (PubMed:27346674, PubMed:27941812). Interacts with RAN. Interacts with HSP70/HSPA1A (PubMed:27941812).INTERACTION Under oxidative stress, migrates from the nucleus to the cytoplasm.ALTERNATIVE PRODUCTS Phosphorylated at Ser-108 by CDK5; leading to protection of the cell against H2O2-induced apoptosis.PTM Ubiquitinated by RNF144A.SIMILARITY Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.CAUTION Inactive as a kinase due to its inability to bind ATP. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Serine/threonine-protein kinase VRK3 ecNumber: 2.7.11.22 alternativeName: Vaccinia-related kinase 3 |
| geneName | VRK3 |
| identifier | Q8IV63 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Transferase Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | VRK3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989311] ENSEMBL:ENSG00000105053 VRK3 [Homo sapiens] |
| secondaryIdentifier | VRK3_HUMAN A6NEG5 A8KA53 Q502Y2 Q9P2V8 |
| sequenceLength | 474 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q8IV63-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8IV63-1 VRK3 (410802)
