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Details on Person UniProt:Q86VP1-1 TAX1BP1
| Class:Id | ReferenceIsoform:409879 |
|---|---|
| _chainChangeLog | chain:1-789 added on Fri February 6 2015 |
| _displayName | UniProt:Q86VP1-1 TAX1BP1 |
| _timestamp | 2025-05-21 21:39:54 |
| chain | chain:1-789 |
| checksum | DE8460DAA6712125 |
| comment | FUNCTION Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289).SUBUNIT Homooligomer. Interacts with TNFAIP3. Interacts with STARD13. Interacts with MYO6 (PubMed:31371777). Interacts with TOM1; the interaction is indirect and is mediated by MYO6, which acts as a bridge between TOM1 and TAX1BP1 (PubMed:31371777). Interacts with MAVS; this interaction induces MAVS polyubiquitination (PubMed:27736772). Interacts with TNIP1 (PubMed:21885437). Interacts with TRAF6; this interaction mediates deubiquitination of TRAF6 and inhibition of NF-kappa-B activation (PubMed:17703191). Interacts with RIPK1; this interaction negatively regulates RIPK1 ubiquitination (PubMed:17703191). Interacts with NBR1 (PubMed:33226137, PubMed:34471133). Interacts with TBK1 (PubMed:33226137). Interacts with RB1CC1 (PubMed:33226137, PubMed:34471133). Interacts with SQSTM1 (PubMed:34471133). Interacts with AZI2 (PubMed:30459273). Interacts with TICAM1 and TRIM32; these interactions target TICAM1 to TAX1BP1-mediated selective autophagic degradation (PubMed:28898289).SUBUNIT (Microbial infection) Interacts with the HTLV-1 protein Tax.SUBUNIT (Microbial infection) Interacts with Respiratory syncytial virus protein N; this interaction may promote viral growth by inhibiting the innate immune response.SUBUNIT (Microbial infection) Interacts with Lassa virus protein Z.SUBUNIT (Microbial infection) Interacts with Mopeia virus protein Z.INTERACTION Expressed in all tissues tested.DOMAIN The C-terminal UBZ-type zinc fingers function as ubiquitin-binding domains.PTM Phosphorylated in the C-terminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Tax1-binding protein 1 alternativeName: TRAF6-binding protein |
| geneName | TAX1BP1 T6BP PRO0105 |
| identifier | Q86VP1 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Apoptosis Autophagy Coiled coil Cytoplasm Cytoplasmic vesicle Host-virus interaction Immunity Innate immunity Metal-binding Mitochondrion Phosphoprotein Proteomics identification Reference proteome Repeat Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | TAX1BP1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994545] ENSEMBL:ENSG00000106052 TAX1BP1 [Homo sapiens] |
| secondaryIdentifier | TAXB1_HUMAN A4D196 B4DKU7 E7ENV2 O60398 O95770 Q13311 Q9BQG5 Q9UI88 |
| sequenceLength | 789 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q86VP1-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q86VP1-1 TAX1BP1 (409879)
