Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q7Z6J4 FGD2
| Class:Id | ReferenceGeneProduct:409503 |
|---|---|
| _chainChangeLog | chain:1-655 added on Sat February 7 2015 |
| _displayName | UniProt:Q7Z6J4 FGD2 |
| _timestamp | 2024-11-03 20:14:25 |
| chain | chain:1-655 |
| checksum | DB60098249C2B340 |
| comment | FUNCTION Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity).INTERACTION Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides.ALTERNATIVE PRODUCTS The FYVE-type zinc-finger is necessary for early endosome localization. Recruitment to endosomal membranes via this domain requires the presence of phosphatidylinositol 3-phosphate or other phosphatidylinositides (By similarity).DOMAIN The PH domain is necessary for localization to the ruffle membrane. Recruitment to ruffle membrane occurs through binding of phosphoinositides by the PH domain. This domain also contributes to the lipid-binding properties of the protein (By similarity).DOMAIN The DH domain is necessary for its ability to activate JNK1 via CDC42.MISCELLANEOUS May be due to an intron retention.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: FYVE, RhoGEF and PH domain-containing protein 2 alternativeName: Zinc finger FYVE domain-containing protein 4 |
| geneName | FGD2 ZFYVE4 |
| identifier | Q7Z6J4 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cell membrane Cell projection Cytoplasm Cytoskeleton Endosome Guanine-nucleotide releasing factor Membrane Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | FGD2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8987826] ENSEMBL:ENSG00000146192 FGD2 [Homo sapiens] |
| secondaryIdentifier | FGD2_HUMAN Q5T8I1 Q6P6A8 Q6ZNL5 Q8IZ32 Q8N868 Q9H7M2 |
| sequenceLength | 655 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:195086] UniProt:Q7Z6J4-4 FGD2 [Homo sapiens] [ReferenceIsoform:195091] UniProt:Q7Z6J4-1 FGD2 [Homo sapiens] [ReferenceIsoform:195111] UniProt:Q7Z6J4-2 FGD2 [Homo sapiens] [ReferenceIsoform:195114] UniProt:Q7Z6J4-5 FGD2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:3000203] FGD2 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q7Z6J4 FGD2 (409503)
