Query author contributions in Reactome
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Details on Person UniProt:Q7Z628 NET1
| Class:Id | ReferenceGeneProduct:409492 |
|---|---|
| _chainChangeLog | chain:1-596 added on Sat February 7 2015 |
| _displayName | UniProt:Q7Z628 NET1 |
| _timestamp | 2024-11-03 19:35:09 |
| chain | chain:1-596 |
| checksum | E1AD964F14650D2C |
| comment | FUNCTION Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.SUBUNIT Interacts with RHOA in its GTP- and GDP-bound states, and with CDC42 in its GTP-bound state. Interacts with the PDZ 1 domain of BAIAP1 (By similarity).INTERACTION Widely expressed.INDUCTION By TGFB1. Up-regulated by DNA damaging agents like H(2)O(2) or ionizing radiation (IR). |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Neuroepithelial cell-transforming gene 1 protein alternativeName: Proto-oncogene p65 Net1 alternativeName: Rho guanine nucleotide exchange factor 8 |
| geneName | NET1 ARHGEF8 |
| identifier | Q7Z628 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cytoplasm Guanine-nucleotide releasing factor Nucleus Phosphoprotein Proteomics identification Proto-oncogene Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | NET1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001608] ENSEMBL:ENSG00000173848 NET1 [Homo sapiens] |
| secondaryIdentifier | ARHG8_HUMAN Q12773 Q96D82 Q99903 Q9UEN6 |
| sequenceLength | 596 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:194991] UniProt:Q7Z628-1 NET1 [Homo sapiens] [ReferenceIsoform:195003] UniProt:Q7Z628-2 NET1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:3006799] NET1 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q7Z628 NET1 (409492)
