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Details on Person p120-RasGAP activates GTP hydrolysis on RAS, inactivating it

Class:Id	Reaction:4093339
_displayName	p120-RasGAP activates GTP hydrolysis on RAS, inactivating it
_doRelease	TRUE
_timestamp	2015-05-15 16:20:22
authored	[InstanceEdit:3928653] Garapati, P V, 2013-07-22
catalystActivity	[CatalystActivity:4093338] GTPase activator activity of p-EPHBs:EFNBs:RASA1:HRAS:GTP [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643192] GTPase activator activity of p-EPHBs:EFNBs:RASA1:HRAS:GTP [plasma membrane] Regulation of the Ras signaling pathway by GTPase-activating protein in PC12 cells
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:4093334] Garapati, P V, 2013-08-14
edited	[InstanceEdit:3928653] Garapati, P V, 2013-07-22
entityOnOtherCell	[DefinedSet:3928378] EFNBs [plasma membrane] [Homo sapiens]
input	[Complex:4093319] p-EPHBs:EFNBs:RASA1:HRAS:GTP [plasma membrane] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:4093301] Regulation of the Ras signaling pathway by GTPase-activating protein in PC12 cells [LiteratureReference:4093292] Suppression of c-ras transformation by GTPase-activating protein
modified	[InstanceEdit:4443762] Garapati, P V, 2013-09-03 [InstanceEdit:4640897] Garapati, P V, 2013-09-27 [InstanceEdit:5096527] Garapati, P V, 2013-11-11 [InstanceEdit:5096559] Garapati, P V, 2013-11-11 [InstanceEdit:5097236] Garapati, P V, 2013-11-11 [InstanceEdit:5099816] Garapati, P V, 2013-11-12 [InstanceEdit:5144541] Garapati, P V, 2013-11-18 [InstanceEdit:5490336] Garapati, P V, 2014-05-19 [InstanceEdit:5693460] D'Eustachio, Peter, 2015-05-15 [InstanceEdit:5693499] Garapati, Phani Vijay, 2015-05-15 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p120-RasGAP activates GTP hydrolysis on RAS, inactivating it
output	[Complex:4093320] p-EPHBs:EFNBs:RASA1:HRAS:GDP [plasma membrane] [Homo sapiens] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:4093331] Ras:GTP binds p120-RasGAP [Homo sapiens] [Reaction:4093330] EPHB binds p120-RasGAP [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5490284] Ip, Nancy Y, 2014-05-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5645155] R-HSA-4093339.3
summation	[Summation:4093276] The p120-RasGAP C-terminus contains a GAP domain that cataly...
(hasEvent)	[Pathway:3928662] EPHB-mediated forward signaling [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784840] Update Tracker - [Reaction:4093339] p120-RasGAP activates GTP hydrolysis on RAS, inactivating it - v53:[add_removeInput, add_removeOutput]
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