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Details on Person The p120-RasGAP C-terminus contains a GAP domain that cataly...
| Class:Id | Summation:4093276 |
|---|---|
| _displayName | The p120-RasGAP C-terminus contains a GAP domain that cataly... |
| _timestamp | 2013-08-14 14:49:04 |
| created | [InstanceEdit:4093269] Garapati, P V, 2013-08-14 |
| literatureReference | [LiteratureReference:4093258] Manipulation of EphB2 regulatory motifs and SH2 binding sites switches MAPK signaling and biological activity [LiteratureReference:4093265] Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction |
| text | The p120-RasGAP C-terminus contains a GAP domain that catalyses the activation of H-Ras by hydrolyzing GTP-bound active Ras into an inactive GDP-bound form of Ras. Inactivation of H-Ras by EPHB2 down regulates MAP kinase phosphorylation and induces neurite retraction in neuronal cells (Elowe et al. 2001, Tong et al. 2003). |
| (summation) | [Reaction:4093339] p120-RasGAP activates GTP hydrolysis on RAS, inactivating it [Homo sapiens] |
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No pathways have been reviewed or authored by The p120-RasGAP C-terminus contains a GAP domain that cataly... (4093276)
