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Details on Person UniProt:Q7LFX5-1 CHST15
| Class:Id | ReferenceIsoform:409268 |
|---|---|
| _chainChangeLog | chain:1-561 added on Fri February 6 2015 |
| _displayName | UniProt:Q7LFX5-1 CHST15 |
| _timestamp | 2025-02-21 19:16:26 |
| chain | chain:1-561 |
| checksum | 74643A7CFF7F242D |
| comment | FUNCTION Sulfotransferase that transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B-cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo.CATALYTIC ACTIVITY dermatan 4'-sulfate + n 3'-phosphoadenylyl sulfate = dermatan 4',6'-bissulfate + n adenosine 3',5'-bisphosphate + n H(+)CATALYTIC ACTIVITY chondroitin 4'-sulfate + n 3'-phosphoadenylyl sulfate = chondroitin 4',6'-bissulfate + n adenosine 3',5'-bisphosphate + n H(+)COFACTOR Inhibited by phenyl beta-GalNAc(4,6-SO(4)).SUBUNIT Homodimer; disulfide-linked (Potential). The relevance of homodimerization is however unsure. May interact with phosphorylated proteins in resting B-cells, including HCK.INTERACTION A small fraction may also be present at the cell surface, where it acts as a B-cell receptor.ALTERNATIVE PRODUCTS Expressed in B-cell-enriched tissues but not in fetal or adult thymus. Expressed in fetal and adult spleen, lymph node, tonsil, bone marrow and peripheral leukocytes. Not expressed in T-cells. In pro-B, pre-B, and mature B-cell lines, it colocalizes with RAG1.PTM Glycosylated.SIMILARITY Belongs to the sulfotransferase 1 family. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Carbohydrate sulfotransferase 15 ecNumber: 2.8.2.33 alternativeName: B-cell RAG-associated gene protein shortName: hBRAG alternativeName: N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase shortName: GalNAc4S-6ST |
| geneName | CHST15 BRAG GALNAC4S6ST KIAA0598 |
| identifier | Q7LFX5 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Disulfide bond Glycoprotein Golgi apparatus Membrane Proteomics identification Reference proteome Signal-anchor Transferase Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | CHST15 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000508] ENSEMBL:ENSG00000182022 CHST15 [Homo sapiens] |
| secondaryIdentifier | CHSTF_HUMAN O60338 O60474 Q86VM4 |
| sequenceLength | 561 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q7LFX5-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q7LFX5-1 CHST15 (409268)
