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Details on Person UniProt:Q6ZQ08-1 Cnot1
| Class:Id | ReferenceIsoform:408927 |
|---|---|
| _chainChangeLog | chain:1-2375 added on Fri February 6 2015 |
| _displayName | UniProt:Q6ZQ08-1 Cnot1 |
| _timestamp | 2026-02-20 22:08:08 |
| chain | chain:1-2375 |
| checksum | 7771515027BA4B60 |
| comment | FUNCTION Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:34733855). Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity; prevents their differentiation towards extraembryonic trophectoderm lineages. Plays a role in rapid sperm motility via mediating timely mRNA turnover (PubMed:34733855).SUBUNIT Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits (By similarity). In the complex, interacts directly with CNOT6, CNOT6L, CNOT7 or CNOT8 (By similarity). Interacts in a ligand-dependent fashion with ESR1 and RXRA (By similarity). Interacts with NANOS2, TOB1 and ZFP36 (PubMed:20133598). Interacts with TNRC6A, TNRC6B or TNRC6C; the interactions are direct (By similarity). Interacts with YTHDF2; the interaction is direct and promotes recruitment of the CCR4-NOT complex to N6-methyladenosine (m6A)-containing mRNAs, leading to their deadenylation and subsequent degradation (PubMed:32905781). Interacts with EIF4ENIF1/4E-T (By similarity). Interacts in an RNA-independent manner with BICC1 (via KH domains) (PubMed:34210974). Interacts with TEX13A; the interaction may inhibit CNOT1 binding to mRNA and subsequently CNOT1-mediated mRNA degradation (PubMed:34733855). Interacts with HELZ (By similarity).INTERACTION NANOS2 promotes its localization to P-body.ALTERNATIVE PRODUCTS Expressed in embryonic stem (ES) cells and in inner cell mass (ICM) of the blastocyst. At 8.25 dpc it is expressed in both the neuroectoderm and mesenchyme of the neural folds but not in extra-embryonic membranes (PubMed:31006510).DOMAIN Contains Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, a motif known to be important for the association with nuclear receptors.SIMILARITY Belongs to the CNOT1 family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: CCR4-NOT transcription complex subunit 1 alternativeName: CCR4-associated factor 1 |
| geneName | Cnot1 Kiaa1007 |
| identifier | Q6ZQ08 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cytoplasm Developmental protein Nucleus Phosphoprotein Reference proteome Repressor RNA-mediated gene silencing Transcription Transcription regulation Translation regulation |
| modified | [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9645038] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9688885] Weiser, JD [InstanceEdit:9706439] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | Cnot1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CNOT1_MOUSE B2RY28 Q3UPB7 Q8BSB4 Q8BXB2 Q8C0H2 Q8K3D8 |
| sequenceLength | 2375 |
| species | [Species:48892] Mus musculus |
| variantIdentifier | Q6ZQ08-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q6ZQ08-1 Cnot1 (408927)
