Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q6ZMT4-1 KDM7A
| Class:Id | ReferenceIsoform:408872 |
|---|---|
| _chainChangeLog | chain:1-941 added on Fri February 6 2015 |
| _displayName | UniProt:Q6ZMT4-1 KDM7A |
| _timestamp | 2025-02-21 18:57:56 |
| chain | chain:1-941 |
| checksum | AB8161020D157F11 |
| comment | FUNCTION Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (PubMed:20023638, PubMed:20622853). Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3 (PubMed:20023638). Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate (PubMed:20622853).CATALYTIC ACTIVITY N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2CATALYTIC ACTIVITY N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(27)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2CATALYTIC ACTIVITY N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2-oxoglutarate + O2 = N(6)-methyl-L-lysyl(36)-[histone H3] + formaldehyde + succinate + CO2CATALYTIC ACTIVITY N(6)-methyl-L-lysyl(20)-[histone H4] + 2-oxoglutarate + O2 = L-lysyl(20)-[histone H4] + formaldehyde + succinate + CO2COFACTOR Binds 1 Fe(2+) ion per subunit.BIOPHYSICOCHEMICAL PROPERTIES The PHD-type zinc finger mediates the binding to H3K4me3. Binding to H3K4me3 prevents its access to H3K9me2.DOMAIN The linker region is a critical determinant of demethylase specificity. It prevents the active site of JmjC to reach the target H3K9me2 when the PHD-type zinc finger binds to H3K4me3, while it favors selectivity toward H3K27me2.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.SIMILARITY Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Lysine-specific demethylase 7A alternativeName: JmjC domain-containing histone demethylation protein 1D alternativeName: Lysine-specific demethylase 7 alternativeName: [histone H3]-dimethyl-L-lysine9 demethylase 7A ecNumber evidence="6 7"1.14.11.65 |
| geneName | KDM7A JHDM1D KDM7 KIAA1718 |
| identifier | Q6ZMT4 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Chromatin regulator Dioxygenase Iron Metal-binding Neurogenesis Nucleus Oxidoreductase Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | KDM7A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000118] ENSEMBL:ENSG00000006459 KDM7A [Homo sapiens] |
| secondaryIdentifier | KDM7A_HUMAN A4D1S9 C9JJH9 C9JQU2 Q6MZL8 Q9C0E5 |
| sequenceLength | 941 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q6ZMT4-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q6ZMT4-1 KDM7A (408872)
