Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Once in the cytosol, sialic acids are either reutilized or d...
| Class:Id | Summation:4088180 |
|---|---|
| _displayName | Once in the cytosol, sialic acids are either reutilized or d... |
| _timestamp | 2014-01-08 11:21:55 |
| created | [InstanceEdit:4088171] Jassal, B, 2013-08-12 |
| modified | [InstanceEdit:5225588] Jassal, Bijay, 2014-01-08 |
| text | Once in the cytosol, sialic acids are either reutilized or degraded. N-acetylneuraminate lyase (NPL) is a cytosolic, tetrameric enzyme that can cleave the major sialic acids N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) to form N-acetylmannosamine (ManNAc) and N-glycolylmannosamine (ManNGc) respectively (Wu et al. 2005). Although humans cannot form Neu5Gc due to a non-functional CMAHP enzyme, Neu5Gc can be ingested by dietary means and must therefore be degraded to avoid accumulation of this immunoreactive sialic acid (Bergfeld et al. 2012). |
| (summation) | [Reaction:4085217] NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Once in the cytosol, sialic acids are either reutilized or d... (4088180)
