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Details on Person PLK1 phosphorylates FOXM1

Class:IdReaction:4088134
_displayNamePLK1 phosphorylates FOXM1
_doReleaseTRUE
_timestamp2013-09-05 11:43:17
authored[InstanceEdit:4127414] Orlic-Milacic, M, 2013-08-14
catalystActivity[CatalystActivity:4088132] protein serine/threonine kinase activity of p-T611-FOXM1:p-T210-PLK1 [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:4088131] Orlic-Milacic, M, 2013-08-09
edited[InstanceEdit:4088131] Orlic-Milacic, M, 2013-08-09
input[Complex:4088136] p-T611-FOXM1:p-T210-PLK1 [nucleoplasm] [Homo sapiens]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
isChimericFALSE
literatureReference[LiteratureReference:4088046] Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression
modified[InstanceEdit:4088138] Orlic-Milacic, M, 2013-08-09
[InstanceEdit:4410469] Orlic-Milacic, M, 2013-08-23
[InstanceEdit:4410475] Orlic-Milacic, M, 2013-08-23
[InstanceEdit:4410476] Orlic-Milacic, M, 2013-08-23
[InstanceEdit:4410477] Orlic-Milacic, M, 2013-08-23
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePLK1 phosphorylates FOXM1
output[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[EntityWithAccessionedSequence:3002800] p-T210-PLK1 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:4088133] p-T611,S730,S739-FOXM1 [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2013-09-18
reviewed[InstanceEdit:4410473] Bruinsma, Wytse, 2013-08-21
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:4545130] R-HSA-4088134.2
summation[Summation:4088129] PLK1 phosphorylates FOXM1 on serine residues S730 and S739 (...
(hasEvent)[Pathway:156711] Polo-like kinase mediated events [Homo sapiens]
(precedingEvent)[NegativePrecedingEvent:9764026] Futile Cycle: PLK1 phosphorylates FOXM1
[NegativePrecedingEvent:9764030] Futile Cycle: PLK1 phosphorylates FOXM1
[NegativePrecedingEvent:9764033] Futile Cycle: PLK1 phosphorylates FOXM1
[NegativePrecedingEvent:9764036] Futile Cycle: PLK1 phosphorylates FOXM1
[Reaction:4088162] FOXM1 binds CDC25A promoter [Homo sapiens]
[Reaction:4088306] FOXM1 binds PLK1 promoter [Homo sapiens]
[Reaction:4088307] FOXM1 binds CCNB1 promoter [Homo sapiens]
[Reaction:4088309] FOXM1 binds CCNB2 promoter [Homo sapiens]
[Reaction:4088439] FOXM1 binds CENPF promoter [Homo sapiens]
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No pathways have been reviewed or authored by PLK1 phosphorylates FOXM1 (4088134)