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Details on Person CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1

Class:Id	Reaction:4088024
_displayName	CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1
_doRelease	TRUE
_timestamp	2022-02-08 21:54:28
authored	[InstanceEdit:4127414] Orlic-Milacic, M, 2013-08-14
catalystActivity	[CatalystActivity:4088033] cyclin-dependent protein serine/threonine kinase activity of p-CDK1/2:CCNA/p-T161-CDK1:CCNB1 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4088032] Orlic-Milacic, M, 2013-08-08
edited	[InstanceEdit:4088032] Orlic-Milacic, M, 2013-08-08
input	[EntityWithAccessionedSequence:4088019] FOXM1 [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:4088059] Forkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivators [LiteratureReference:4088029] Activation of FoxM1 during G2 requires cyclin A/Cdk-dependent relief of autorepression by the FoxM1 N-terminal domain [LiteratureReference:4088046] Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression
modified	[InstanceEdit:4088040] Orlic-Milacic, M, 2013-08-09 [InstanceEdit:4088062] Orlic-Milacic, M, 2013-08-09 [InstanceEdit:4088063] Orlic-Milacic, M, 2013-08-09 [InstanceEdit:4088137] Orlic-Milacic, M, 2013-08-09 [InstanceEdit:4410469] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:4410475] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:4410476] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:4410477] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:9006375] Orlic-Milacic, Marija, 2017-05-15 [InstanceEdit:9006376] Orlic-Milacic, Marija, 2017-05-15 [InstanceEdit:9764017] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9764050] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1
negativePrecedingEvent	[NegativePrecedingEvent:9764044] Futile Cycle: PP2A-PPP2R2A dephosphorylates FOXM1
output	[EntityWithAccessionedSequence:4088026] p-T611-FOXM1 [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent	[Reaction:170158] CDC25A dephosphorylates CCNA:CDK1 [Homo sapiens] [Reaction:170156] WEE1 phosphorylates CCNA:CDK1 [Homo sapiens] [BlackBoxEvent:4088152] FOXM1 stimulates CDC25A transcription [Homo sapiens] [Reaction:170159] Translocation of Cdc25 to the nucleus [Homo sapiens] [BlackBoxEvent:188345] The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex [Homo sapiens] [Reaction:170153] Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases [Homo sapiens] [Reaction:170159] Translocation of Cdc25 to the nucleus [Homo sapiens] [Reaction:170131] Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes [Homo sapiens] [Reaction:156699] Inactivation of Wee1 kinase [Homo sapiens] [BlackBoxEvent:4088152] FOXM1 stimulates CDC25A transcription [Homo sapiens] [Reaction:170044] Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus [Homo sapiens] [Reaction:170149] Translocation of active Cdc25C to the nucleus [Homo sapiens] [Reaction:170070] Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes [Homo sapiens]
releaseDate	2013-09-18
reviewed	[InstanceEdit:4410473] Bruinsma, Wytse, 2013-08-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:4545235] R-HSA-4088024.4
summation	[Summation:4088038] In the G2 phase of the cell cycle, cyclin A (CCNA) and B (CC...
(hasEvent)	[Pathway:69273] Cyclin A/B1/B2 associated events during G2/M transition [Homo sapiens]
(precedingEvent)	[Reaction:4088130] PLK1 binds FOXM1 [Homo sapiens] [Reaction:4088141] PP2A-PPP2R2A dephosphorylates FOXM1 [Homo sapiens]
(replacementInstances)	[_Deleted:9953045] Deletion of instance: 69756 [_Deleted:9953047] Deletion of instance: 69754
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No pathways have been reviewed or authored by CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (4088024)