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Details on Person CCNB:CDK1 phosphorylates BORA

Class:Id	Reaction:4086410
_displayName	CCNB:CDK1 phosphorylates BORA
_doRelease	TRUE
_timestamp	2025-01-22 15:37:09
authored	[InstanceEdit:3004457] Orlic-Milacic, M, 2013-01-28
catalystActivity	[CatalystActivity:2311326] cyclin-dependent protein serine/threonine kinase activity of CCNB1,CCNB2:p-T161-CDK1 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:4086408] Orlic-Milacic, M, 2013-08-08
edited	[InstanceEdit:3006289] Orlic-Milacic, M, 2013-01-29 [InstanceEdit:9929843] Orlic-Milacic, Marija, 2024-11-28
input	[EntityWithAccessionedSequence:2562607] BORA [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:2565943] Mitotic activation of the kinase Aurora-A requires its binding partner Bora [LiteratureReference:4086413] Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora [LiteratureReference:9929593] Cdk1 Phosphorylates SPAT-1/Bora to Promote Plk1 Activation in C. elegans and Human Cells [LiteratureReference:9929541] Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1
modified	[InstanceEdit:4086417] Orlic-Milacic, M, 2013-08-08 [InstanceEdit:4410469] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:4410475] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:4410476] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:4410477] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:9764017] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9929539] Orlic-Milacic, Marija, 2024-11-26 [InstanceEdit:9929607] Orlic-Milacic, Marija, 2024-11-26 [InstanceEdit:9929801] Orlic-Milacic, Marija, 2024-11-28 [InstanceEdit:9932263] Orlic-Milacic, Marija, 2024-12-18 [InstanceEdit:9936323] Orlic-Milacic, Marija, 2025-01-22
name	CCNB:CDK1 phosphorylates BORA
output	[EntityWithAccessionedSequence:4086411] p-7S,2T-BORA [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:170161] Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B [Homo sapiens] [Reaction:162657] Inactivation of Myt1 kinase [Homo sapiens] [Reaction:170120] Translocation of Cdc25B to the cytoplasm [Homo sapiens] [Reaction:170072] Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm [Homo sapiens] [BlackBoxEvent:9929533] CCNA:CDK1 complex translocates to the cytosol [Homo sapiens] [Reaction:9929514] CDK1 phosphorylates CCNA [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2013-09-18
reviewed	[InstanceEdit:4410473] Bruinsma, Wytse, 2013-08-21 [InstanceEdit:9936318] Alwakeel, Alan, 2025-01-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:4545207] R-HSA-4086410.4
structureModified	[InstanceEdit:9929607] Orlic-Milacic, Marija, 2024-11-26 [InstanceEdit:9929801] Orlic-Milacic, Marija, 2024-11-28
summation	[Summation:4086415] CDK1 in complex with cyclin B was shown to phosphorylate bot...
(hasEvent)	[Pathway:2565942] Regulation of PLK1 Activity at G2/M Transition [Homo sapiens]
(precedingEvent)	[Reaction:3000319] BORA binds PLK1 and AURKA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9939795] Update Tracker - [Reaction:4086410] CCNB:CDK1 phosphorylates BORA - v92:[modifyText, removeLiteratureReference]
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