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Details on Person Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP

Class:Id	LiteratureReference:4086381
_displayName	Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP
_timestamp	2013-08-07 20:46:05
author	[Person:4086346] Ahumada, Adriana [Person:3965162] Slusarski, Diane C [Person:3965253] Liu, Xunxian [Person:196211] Moon, Randall T [Person:3965256] Malbon, Craig C [Person:3772277] Wang, Hsien-Yu
created	[InstanceEdit:4086382] Rothfels, K, 2013-08-07
journal	Science
pages	2006-10
pubMedIdentifier	12471263
title	Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP
volume	298
year	2002
(literatureReference)	[Reaction:3965447] G-protein subunits dissociate from WNT:FZD complex [Homo sapiens] [Reaction:4086392] PDE6 hydrolyses cGMP to GMP [Homo sapiens] [Reaction:4086393] G alpha t2 binds and activates PDE6 [Homo sapiens] [Reaction:4086394] Gnat2 binds and activates Pde6 [Mus musculus] [Reaction:4420052] Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT [Homo sapiens] [Reaction:4551446] Prkg is activated upon cGMP binding [Mus musculus] [Reaction:4551453] PRKG is activated by binding to high levels of cGMP in the absence of WNT signaling [Homo sapiens]
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