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Details on Person Thrombospondin-1 (THBS1) is a trimeric protein held together...

Class:Id	Summation:4086221
_displayName	Thrombospondin-1 (THBS1) is a trimeric protein held together...
_timestamp	2013-08-07 15:58:05
created	[InstanceEdit:4086135] Jupe, S, 2013-08-07
literatureReference	[LiteratureReference:4086193] Synthesis of truncated amino-terminal trimers of thrombospondin [LiteratureReference:4086109] Isolation and characterization of a high molecular weight glycoprotein from human blood platelets [LiteratureReference:4086142] Binding and degradation of thrombospondin-1 mediated through heparan sulphate proteoglycans and low-density-lipoprotein receptor-related protein: localization of the functional activity to the trimeric N-terminal heparin-binding region of thrombospondin-1 [LiteratureReference:4086165] Thrombospondin-1: multiple paths to inflammation [LiteratureReference:4086151] Isolation of the thrombospondin membrane receptor [LiteratureReference:4086118] Disulfides modulate RGD-inhibitable cell adhesive activity of thrombospondin [LiteratureReference:4086196] Identification of integrin alpha 3 beta 1 as a neuronal thrombospondin receptor mediating neurite outgrowth [LiteratureReference:4086159] Activated T-cell adhesion to thrombospondin is mediated by the alpha 4 beta 1 (VLA-4) and alpha 5 beta 1 (VLA-5) integrins [LiteratureReference:4086161] Recognition of the N-terminal modules of thrombospondin-1 and thrombospondin-2 by alpha6beta1 integrin [LiteratureReference:4086129] Alpha4beta1 integrin mediates selective endothelial cell responses to thrombospondins 1 and 2 in vitro and modulates angiogenesis in vivo [LiteratureReference:4086180] Trimeric assembly of the C-terminal region of thrombospondin-1 or thrombospondin-2 is necessary for cell spreading and fascin spike organisation
modified	[InstanceEdit:4086244] Jupe, S, 2013-08-07
text	Thrombospondin-1 (THBS1) is a trimeric protein held together by interchain disulphide bonds at Cys-252 and Cys-256 (Sottile et al. 1991). It was originally identified as a platelet alpha granule protein (Lawler et al. 1978) and subsequently found to be produced and secreted by a number of cell types such as endothelial cells, fibroblasts, adipocytes, smooth muscle cells, monocytes, macrophages, and transformed cells such as malignant glioma cells. Proposed functions include an involvement in platelet aggregation, cell adhesion, cell growth, angiogenesis, binding and activation of latent transforming growth factor-b and regulation of protease activities (Chen et al. 1996, Lopez-Dee et al. 2011). Several TSP-1 receptors have been identified, including CD36 (Asch et al. 1987) and several integrins including alphavbeta3 (Sun et al. 1992), alpha3beta1 (DeFreitas et al. 1995), alpha4beta1, alpha5beta1 (Yabowitz et al. 1993), and either alpha2bbeta3 or alpha2beta1 (Tuszynski & Kowalska 1991). Integrins alpha4beta1 and alpha6beta1 binds THBS1 and the related trimeric THBS2 (Anilkumar et al. 2002, Calzada et al. 2003, 2004).
(summation)	[Reaction:4086185] Thrombospondin 1 and 2 bind integrin alpha6beta1 [Homo sapiens]
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