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Details on Person UniProt:Q6P2C8 MED27
| Class:Id | ReferenceGeneProduct:408420 |
|---|---|
| _chainChangeLog | chain:1-311 added on Fri February 6 2015 |
| _displayName | UniProt:Q6P2C8 MED27 |
| _timestamp | 2024-11-03 20:10:45 |
| chain | chain:1-311 |
| checksum | 996D675993E393CB |
| comment | FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.SUBUNIT Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.INTERACTION The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the Mediator complex subunit 27 family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Truncated C-terminus. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Mediator of RNA polymerase II transcription subunit 27 alternativeName: Cofactor required for Sp1 transcriptional activation subunit 8 shortName: CRSP complex subunit 8 alternativeName: Mediator complex subunit 27 alternativeName: P37 TRAP/SMCC/PC2 subunit alternativeName: Transcriptional coactivator CRSP34 |
| geneName | MED27 CRSP34 CRSP8 |
| identifier | Q6P2C8 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Activator Alternative splicing Cataract Intellectual disability Methylation Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | MED27 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997268] ENSEMBL:ENSG00000160563 MED27 [Homo sapiens] |
| secondaryIdentifier | MED27_HUMAN O95401 Q4F964 Q5VTA4 Q5VTA5 Q9BU57 Q9NYR4 V9GYV9 |
| sequenceLength | 311 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:212208] UniProt:Q6P2C8-2 MED27 [Homo sapiens] [ReferenceIsoform:212211] UniProt:Q6P2C8-1 MED27 [Homo sapiens] [ReferenceIsoform:8971065] UniProt:Q6P2C8-4 MED27 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:556761] MED27 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q6P2C8 MED27 (408420)
