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Details on Person UniProt:Q15648 MED1
| Class:Id | ReferenceGeneProduct:405875 |
|---|---|
| _chainChangeLog | chain:1-1581 added on Fri February 6 2015 |
| _displayName | UniProt:Q15648 MED1 |
| _timestamp | 2026-02-20 23:07:39 |
| chain | chain:1-1581 |
| checksum | FCE0FE87EF08B887 |
| comment | FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).SUBUNIT Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. This subunit specifically interacts with a number of nuclear receptors in a ligand-dependent fashion including AR, ESR1, ESR2, PPARA, PPARG, RORA, RXRA, RXRG, THRA, THRB and VDR. Interacts with CTNNB1, GABPA, GLI3, PPARGC1A and TP53. Interacts with YWHAH. Interacts with CLOCK; this interaction requires the presence of THRAP3 (By similarity). Interacts with GATA1 and CCAR1. Interacts with NR4A3 (By similarity). Interacts (via IBM motif) with PSIP1 (via IBD domain); phosphorylation increases its affinity for PSIP1 (PubMed:29997176). Interacts with USP22 (By similarity). Interacts with PRDM16; promoting recruitment of the Mediator complex to chromatin and activation of genes that are highly expressed in brown adipocytes (By similarity).INTERACTION A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3.ALTERNATIVE PRODUCTS Ubiquitously expressed.PTM Phosphorylated by MAPK1 or MAPK3 during G2/M phase which may enhance protein stability and promote entry into the nucleolus (PubMed:16314496). Phosphorylation increases its interaction with PSIP1 (PubMed:29997176).SIMILARITY Belongs to the Mediator complex subunit 1 family.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Mediator of RNA polymerase II transcription subunit 1 alternativeName: Activator-recruited cofactor 205 kDa component shortName: ARC205 alternativeName: Mediator complex subunit 1 alternativeName: Peroxisome proliferator-activated receptor-binding protein shortName: PBP shortName: PPAR-binding protein alternativeName: Thyroid hormone receptor-associated protein complex 220 kDa component shortName: Trap220 alternativeName: Thyroid receptor-interacting protein 2 shortName: TR-interacting protein 2 shortName: TRIP-2 alternativeName: Vitamin D receptor-interacting protein complex component DRIP205 alternativeName: p53 regulatory protein RB18A |
| geneName | MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2 |
| identifier | Q15648 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Activator Alternative splicing Direct protein sequencing DNA-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | MED1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998990] ENSEMBL:ENSG00000125686 MED1 [Homo sapiens] |
| secondaryIdentifier | MED1_HUMAN A2RRQ6 O43810 O75447 Q6P9H7 Q6PK58 Q9HD39 |
| sequenceLength | 1581 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:62086] UniProt:Q15648-1 MED1 [Homo sapiens] [ReferenceIsoform:237020] UniProt:Q15648-3 MED1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:212445] MED1 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q15648 MED1 (405875)
