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Details on Person UniProt:Q15007-1 WTAP
| Class:Id | ReferenceIsoform:405806 |
|---|---|
| _chainChangeLog | chain:1-396 added on Sat February 7 2015 |
| _displayName | UniProt:Q15007-1 WTAP |
| _timestamp | 2024-11-03 20:05:23 |
| chain | chain:1-396 |
| checksum | B4F81B3000F77A37 |
| comment | FUNCTION Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).SUBUNIT Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:24316715, PubMed:24407421, PubMed:24981863, PubMed:29348140, PubMed:29506078, PubMed:29507755). The MAC subcomplex is composed of METTL3 and METTL14 (PubMed:29507755). The MACOM subcomplex is composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, and, in some cases of RBM15 (RBM15 or RBM15B) (PubMed:29507755). Interacts with WT1 (PubMed:11001926, PubMed:17095724). Also a component of a MACOM-like complex, named WTAP complex, composed of WTAP, ZC3H13, CBLL1, VIRMA, RBM15, BCLAF1 and THRAP3 (PubMed:24100041).INTERACTION Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus.ALTERNATIVE PRODUCTS Ubiquitously expressed.INDUCTION In smooth muscle cells, up-regulated after serum withdrawal, when cells become mature and non proliferative.SIMILARITY Belongs to the fl(2)d family. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: fullName evidence="21"Pre-mRNA-splicing regulator WTAP alternativeName: fullName evidence="17"Female-lethal(2)D homolog shortName evidence="17"hFL(2)D alternativeName: fullName evidence="16"WT1-associated protein alternativeName: fullName evidence="16"Wilms tumor 1-associating protein |
| geneName | WTAP KIAA0105 |
| identifier | Q15007 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cell cycle Cytoplasm Developmental protein Direct protein sequencing mRNA processing mRNA splicing Nucleus Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | WTAP |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962165] ENSEMBL:ENSG00000146457 WTAP [Homo sapiens] |
| secondaryIdentifier | FL2D_HUMAN Q5TCL8 Q5TCL9 Q96T28 Q9BYJ7 Q9H4E2 |
| sequenceLength | 396 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q15007-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q15007-1 WTAP (405806)
