Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person UniProt:Q13772 NCOA4

Class:Id	ReferenceGeneProduct:405660
_chainChangeLog	chain:1-614 added on Sat February 7 2015
_displayName	UniProt:Q13772 NCOA4
_timestamp	2024-11-03 19:42:08
chain	chain:1-614
checksum	36B6D97C7D072BFF
comment	FUNCTION Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis (PubMed:25327288, PubMed:26436293). Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy (PubMed:25327288, PubMed:26436293). Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion (PubMed:25327288). Ensures efficient erythropoiesis, possibly by regulating hemin-induced erythroid differentiation (PubMed:26436293). In some studies, has been shown to enhance the androgen receptor AR transcriptional activity as well as acting as ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma (PubMed:10347167, PubMed:8643607). Another study shows only weak behavior as a coactivator for the androgen receptor and no alteration of the ligand responsiveness of the AR (PubMed:10517667). Binds to DNA replication origins, binding is not restricted to sites of active transcription and may likely be independent from the nuclear receptor transcriptional coactivator function (PubMed:24910095). May inhibit activation of DNA replication origins, possibly by obstructing DNA unwinding via interaction with the MCM2-7 complex (PubMed:24910095).SUBUNIT Interacts with the ferritin complex, an oligomeric structure composed of varying combinations of ferritin heavy chains and ferritin light chains (PubMed:25327288). Interacts (via C-terminus) with ferritin heavy chain FTH1 (via 'Arg-23'); thereby targeting the iron-binding ferritin complex to autolysosomes following starvation or iron depletion (PubMed:25327288, PubMed:26436293). Interacts with ferritin light chain FTL (PubMed:25327288). Interacts (via C-terminus) with ATG8-like proteins GABARAP and GABARAPL1; thereby mediating localization to autophagosomes and ferritinophagy (By similarity). Interacts with MAP1LC3C/LC3C and GABARAPL2 (By similarity). Interacts with the androgen receptor AR (via NR DNA binding domain and NR LBD) in a ligand-dependent manner (PubMed:10517667, PubMed:15563469, PubMed:8643607). Interacts with the retinoid acid receptor RXR-gamma (RXRG) in a ligand-dependent manner (PubMed:10347167). Interacts (via N-terminus) with MCM7 (PubMed:24910095). Interacts with MCM3 (PubMed:24910095). Interacts with CDC45 (PubMed:24910095).SUBUNIT Interacts (via C-terminus) with ferritin heavy chain FTH1.SUBUNIT Does not interact with ferritin heavy chain FTH1.INTERACTION Additional isoforms seem to exist.TISSUE SPECIFICITY Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform Beta is only expressed in testis.INDUCTION Down-regulated by nutrient deprivation (at protein level).PTM NCOA4 levels may be regulated via HERC2-mediated ubiquitination leading to proteosomal degradation; HERC2 association is dependent on NCOA4 iron occupancy.DISEASE A chromosomal aberration involving NCOA4 is found in papillary thyroid carcinomas (PTCs). Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene.
created	[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
description	recommendedName: fullName evidence="17"Nuclear receptor coactivator 4 shortName evidence="16"NCoA-4 alternativeName: fullName evidence="14"Androgen receptor coactivator 70 kDa protein shortName evidence="14"70 kDa AR-activator shortName evidence="14"70 kDa androgen receptor coactivator alternativeName: fullName evidence="16"Androgen receptor-associated protein of 70 kDa alternativeName: fullName evidence="16"Ferritin cargo receptor NCOA4 alternativeName: fullName evidence="16"Ret-activating protein ELE1
geneName	NCOA4 ARA70 ELE1 RFG
identifier	Q13772
isSequenceChanged	FALSE
keyword	3D-structure Activator Alternative splicing Chromosomal rearrangement Chromosome Cytoplasmic vesicle Lysosome Nucleus Proteomics identification Proto-oncogene Reference proteome Transcription Transcription regulation Ubl conjugation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	NCOA4
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9004830] ENSEMBL:ENSG00000266412 NCOA4 [Homo sapiens]
secondaryIdentifier	NCOA4_HUMAN A8K8W5 B4E260 E9PAV7 J3KQN8 Q14239
sequenceLength	614
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:375209] UniProt:Q13772-2 NCOA4 [Homo sapiens] [ReferenceIsoform:375215] UniProt:Q13772-1 NCOA4 [Homo sapiens] [ReferenceIsoform:8972027] UniProt:Q13772-3 NCOA4 [Homo sapiens] [ReferenceIsoform:8972028] UniProt:Q13772-4 NCOA4 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:8940259] NCOA4 [nucleoplasm] [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by UniProt:Q13772 NCOA4 (405660)