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Details on Person UniProt:Q13362 PPP2R5C

Class:Id	ReferenceGeneProduct:405599
_chainChangeLog	chain:1-524 added on Fri February 6 2015
_displayName	UniProt:Q13362 PPP2R5C
_timestamp	2026-02-20 21:26:57
chain	chain:1-524
checksum	B9CBF54550D713F8
comment	FUNCTION The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.SUBUNIT PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with PPP2CA and PPP2R1A; the interaction is direct. Interacts with SGO1; the interaction is direct. Isoform 1 and isoform 2 interact with TP53 (phosphorylated at Ser-15 by ATM); increased upon DNA damage it drives PP2A-mediated dephosphorylation of TP53 at Thr-55. Interacts with IER3 and/or ERK kinases; regulates ERK dephosphorylation. Interacts with CIP2A; this interaction stabilizes CIP2A (PubMed:28174209).INTERACTION Highest levels in heart, skeletal muscle and brain. Lower levels in pancreas, kidney, lung and placenta. Very low levels in liver.INDUCTION Up-regulated upon DNA damage.PTM Isoform Gamma-3 is phosphorylated on serine residues. Isoform Gamma-1 phosphorylation by ERK2 is IER3-dependent and inhibits ERK dephosphorylation by PP2A-PPP2R5C.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the phosphatase 2A regulatory subunit B56 family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.
created	[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
description	recommendedName: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform alternativeName: PP2A B subunit isoform B'-gamma alternativeName: PP2A B subunit isoform B56-gamma alternativeName: PP2A B subunit isoform PR61-gamma alternativeName: PP2A B subunit isoform R5-gamma alternativeName: Renal carcinoma antigen NY-REN-29
geneName	PPP2R5C KIAA0044
identifier	Q13362
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing Centromere Chromosome Disease variant Intellectual disability Nucleus Phosphoprotein Proteomics identification Reference proteome
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
name	PPP2R5C
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8962303] ENSEMBL:ENSG00000078304 PPP2R5C [Homo sapiens]
secondaryIdentifier	2A5G_HUMAN B4DYJ8 B5BUA5 F5GWP3 Q14391 Q15060 Q15174 Q6ZN33
sequenceLength	524
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:49123] UniProt:Q13362-1 PPP2R5C [Homo sapiens] [ReferenceIsoform:143557] UniProt:Q13362-2 PPP2R5C [Homo sapiens] [ReferenceIsoform:143558] UniProt:Q13362-3 PPP2R5C [Homo sapiens] [ReferenceIsoform:8965449] UniProt:Q13362-4 PPP2R5C [Homo sapiens] [ReferenceIsoform:8965450] UniProt:Q13362-5 PPP2R5C [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:3008946] PPP2R5C [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3008948] PPP2R5C [chromosome, centromeric region] [Homo sapiens] [EntityWithAccessionedSequence:3008954] PPP2R5C [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6811447] p-S337-PPP2R5C [cytosol] [Homo sapiens]
(referenceSequence)	[ModifiedResidue:6811449] O-phospho-L-serine at 337
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No pathways have been reviewed or authored by UniProt:Q13362 PPP2R5C (405599)