Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person UniProt:Q13324-1 CRHR2

Class:IdReferenceIsoform:405593
_chainChangeLogchain:1-411 added on Fri February 6 2015;signal peptide:1-19 added on Fri February 6 2015
_displayNameUniProt:Q13324-1 CRHR2
_timestamp2023-11-03 15:01:09
chainchain:1-411
signal peptide:1-19
checksum96B99A93594CF07F
commentFUNCTION G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.SUBUNIT Monomer. Interacts (via N-terminal extracellular domain) with CRF, UCN, UCN2 and UCN3. Has highest affinity for UCN, and considerably lower affinity for CRF, UNC2 and UCN3.INTERACTION The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape. Transmembrane helix 7 assumes a sharply kinked structure (By similarity).DOMAIN The uncleaved pseudo signal peptide prevents receptor's oligomerization and coupling to G(i) subunits. It is also responsible for the rather low receptor localization at the plasma membrane (PubMed:22689579).PTM A N-glycosylation site within the signal peptide impedes its proper cleavage and function.SIMILARITY Belongs to the G-protein coupled receptor 2 family.
created[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
descriptionrecommendedName: Corticotropin-releasing factor receptor 2 shortName: CRF-R-2 shortName: CRF-R2 shortName: CRFR-2 alternativeName: Corticotropin-releasing hormone receptor 2 shortName: CRH-R-2 shortName: CRH-R2
geneNameCRHR2
CRF2R
CRH2R
identifierQ13324
isoformParent
isSequenceChangedFALSE
keyword3D-structure
Alternative splicing
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Receptor
Reference proteome
Signal
Transducer
Transmembrane
Transmembrane helix
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
nameCRHR2
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:9001700] ENSEMBL:ENSG00000106113 CRHR2 [Homo sapiens]
secondaryIdentifierCRFR2_HUMAN
B2R967
B3SXS6
B3SXS7
B3SXS8
B3SXT0
F8WA81
O43461
Q4QRJ4
Q99431
sequenceLength411
species[Species:48887] Homo sapiens
variantIdentifierQ13324-1
(referenceEntity)[EntityWithAccessionedSequence:8937589] CRHR2-1 [plasma membrane] [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by UniProt:Q13324-1 CRHR2 (405593)
Follow Reactome