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Details on Person UniProt:Q13309 SKP2

Class:Id	ReferenceGeneProduct:405589
_chainChangeLog	chain:1-424 added on Fri February 6 2015
_displayName	UniProt:Q13309 SKP2
_timestamp	2025-08-15 21:49:10
chain	chain:1-424
checksum	F29B7C338A7A37E9
comment	FUNCTION Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:9736735, PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16262255, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22464731, PubMed:22770219, PubMed:32267835). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1 (By similarity). Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, NBN, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22464731, PubMed:32267835). Degradation of TAL1 also requires STUB1 (PubMed:17962192). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (PubMed:9736735, PubMed:16262255). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (PubMed:22770219). Following phosphorylation in response to DNA damage, mediates 'Lys-63'-linked ubiquitination of NBN, promoting ATM recruitment to DNA damage sites and DNA repair via homologous recombination (PubMed:22464731).FUNCTION Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Part of a SCF(SKP2) complex consisting of CUL1, RBX1, SKP1 and SKP2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Interacts directly with CUL1 and SKP1. Interacts with CKS1. Interacts with ASB2 which is the substrate-recognition component of a probable ECS E3 ubiquitin-protein ligase complex; ASB2 is likely to bridge the formation of dimeric E3-ubiquitin-protein ligase complexes composed of an ECS complex and an SCF(SKP2) complex (PubMed:21119685). Interacts with the cyclin-A-CDK2 complex. Interacts with ORC1, phosphorylated CDT1, phosphorylated RBL2, ELF4, phosphorylated RAG2, FOXO1, UBP43, MYC, TOB1, TAL1 and KMT2A/MLL1. Interacts with TRIM21. Interacts with cyclin-E (By similarity). Interacts with IFI27; promotes the ubiquitin-mediated proteasomal degradation of hepatitis C virus/HCV non-structural protein NS5A (PubMed:27194766). Interacts with CARM1 (By similarity).SUBUNIT (Microbial infection) Interacts with hepatitis C virus/HCV non-structural protein NS5A; promotes the ubiquitin-mediated proteasomal degradation of NS5A.INTERACTION Phosphorylated on serine and threonine resudues in response to DNA damage, promoting 'Lys-63'-linked ubiquitination of NBN.PTM Ubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Deubiquitinated by USP13.PTM Acetylation at Lys-68 and Lys-71 increases stability through impairment of APC/C-mediated proteolysis and promotes cytoplasmic retention. Deacetylated by SIRT3.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Probable cloning artifact.
created	[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
description	recommendedName: S-phase kinase-associated protein 2 alternativeName: Cyclin-A/CDK2-associated protein p45 alternativeName: F-box protein Skp2 alternativeName: F-box/LRR-repeat protein 1 alternativeName: p45skp2
geneName	SKP2 FBXL1
identifier	Q13309
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing Antiviral defense Cytoplasm Direct protein sequencing Host-virus interaction Immunity Innate immunity Leucine-rich repeat Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Ubl conjugation Ubl conjugation pathway
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	SKP2
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8962309] ENSEMBL:ENSG00000145604 SKP2 [Homo sapiens]
secondaryIdentifier	SKP2_HUMAN A8K5E0 B4DJT4 Q8TDZ0 Q8TDZ1 Q9BV69
sequenceLength	424
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:101668] UniProt:Q13309-1 SKP2 [Homo sapiens] [ReferenceIsoform:153980] UniProt:Q13309-2 SKP2 [Homo sapiens] [ReferenceIsoform:8971205] UniProt:Q13309-4 SKP2 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:975495] SKP2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:975554] SKP2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9687073] PolyUb-SKP2 [nucleoplasm] [Homo sapiens]
(referenceSequence)	[GroupModifiedResidue:9687070] ubiquitinylated lysine (K11polyUb [nucleoplasm]) at unknown position
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No pathways have been reviewed or authored by UniProt:Q13309 SKP2 (405589)