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Details on Person UniProt:Q02505-1 MUC3A
| Class:Id | ReferenceIsoform:405076 |
|---|---|
| _chainChangeLog | signal peptide:1-21 added on Sat February 7 2015;chain:22-2541 added on Sat February 7 2015;signal peptide:1-21 removed on Fri May 6 2016;chain:22-2541 removed on Fri May 6 2016;signal peptide:1-15 added on Fri May 6 2016;chain:16-3323 added on Fri May 6 2016 |
| _displayName | UniProt:Q02505-1 MUC3A |
| _timestamp | 2024-11-03 19:42:02 |
| chain | signal peptide:1-15 chain:16-3323 |
| checksum | 8C6E21ADD26637EF |
| comment | FUNCTION Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling.SUBCELLULAR LOCATION Additional isoforms seem to exist.TISSUE SPECIFICITY Broad specificity; small intestine, colon, colonic tumors, heart, liver, thymus, prostate, pancreas and gall bladder.PTM Highly O-glycosylated and probably also N-glycosylated.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.SEQUENCE CAUTION This sequence is incomplete at 5' and 3' ends and extensively differs from that shown.SEQUENCE CAUTION This sequence is incomplete at 5' and 3' ends and extensively differs from that shown. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: fullName evidence="11"Mucin-3A shortName evidence="11"MUC-3A alternativeName: fullName evidence="13"Intestinal mucin-3A |
| geneName | MUC3A MUC3 |
| identifier | Q02505 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Disulfide bond EGF-like domain Glycoprotein Membrane Proteomics identification Reference proteome Repeat Secreted Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | MUC3A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996724] ENSEMBL:ENSG00000169894 MUC3A [Homo sapiens] |
| secondaryIdentifier | MUC3A_HUMAN A6NP22 O14650 O14651 O43418 O43421 Q02506 Q6W763 Q9H3Q7 Q9UKW9 Q9UN93 Q9UN94 Q9UN95 |
| sequenceLength | 3323 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q02505-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q02505-1 MUC3A (405076)
