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Details on Person UniProt:P80217-1 IFI35
| Class:Id | ReferenceIsoform:404845 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-286 added on Fri February 6 2015;initiator methionine:1 for 404845 removed on Fri Nov 03 2023;initiator methionine: for 404845 added on Fri Nov 03 2023;initiator methionine: for 404845 removed on Fri Aug 15 2025;initiator methionine:1 for 404845 added on Fri Aug 15 2025 |
| _displayName | UniProt:P80217-1 IFI35 |
| _timestamp | 2025-08-15 21:45:58 |
| chain | initiator methionine:1 chain:2-286 |
| checksum | 3FCAB26E97317508 |
| comment | FUNCTION Acts as a signaling pathway regulator involved in innate immune system response (PubMed:26342464, PubMed:29038465, PubMed:29350881). In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation (PubMed:10779520, PubMed:10950963). In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production (PubMed:26342464). In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion (PubMed:29038465). Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (PubMed:29038465).SUBUNIT Homodimer (PubMed:10950963, PubMed:8288566). Also interacts with BATF (PubMed:8954125). Interacts with TRIM21 (PubMed:26342464). Interacts with NMI; the interaction is direct and is facilitated by TRIM21 (PubMed:10779520, PubMed:10950963, PubMed:26342464).INTERACTION Cytoplasmic IFI35 localizes in punctate granular structures (PubMed:10950963). Nuclear localization increased is stimulated by IFN-alpha (PubMed:10950963, PubMed:8288566). Extracelullar following secretion by macrophage (PubMed:29038465).ALTERNATIVE PRODUCTS Expressed in a wide range of cell types, including fibroblasts, macrophages, and epithelial cells.INDUCTION Up-regulated by interferons IFN-alpha and IFN-gamma.DOMAIN The NID domain 1 is involved in the negative regulation of p65/RELA transcription and the negative regulation of NF-kappa-B pathway activation.PTM Phosphorylated. Dephosphorylation correlates with the formation of a complex with NMI.MISCELLANEOUS Due to a polymorphism at the 3'-splice acceptor site of intron 4.SIMILARITY Belongs to the NMI family.SEQUENCE CAUTION Contaminating sequence. Sequence of unknown origin in the N-terminal part. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: fullName evidence="15"Interferon-induced 35 kDa protein shortName evidence="13 15"IFP 35 shortName evidence="12 14"Ifi-35 |
| geneName | IFI35 IFP35 |
| identifier | P80217 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cytoplasm Direct protein sequencing Immunity Innate immunity Nucleus Phosphoprotein Proteomics identification Reference proteome Secreted |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | IFI35 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962255] ENSEMBL:ENSG00000068079 IFI35 [Homo sapiens] |
| secondaryIdentifier | IN35_HUMAN C9JGX1 Q92984 Q99537 Q9BV98 |
| sequenceLength | 286 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P80217-1 |
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No pathways have been reviewed or authored by UniProt:P80217-1 IFI35 (404845)
