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Details on Person UniProt:P78324 SIRPA
| Class:Id | ReferenceGeneProduct:404821 |
|---|---|
| _chainChangeLog | signal peptide:1-30 added on Fri February 6 2015;chain:31-504 added on Fri February 6 2015 |
| _displayName | UniProt:P78324 SIRPA |
| _timestamp | 2024-11-03 19:58:36 |
| chain | signal peptide:1-30 chain:31-504 |
| checksum | 18D2FD04F6182AD0 |
| comment | FUNCTION Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization (By similarity). Receptor for THBS1 (PubMed:24511121). Interaction with THBS1 stimulates phosphorylation of SIRPA (By similarity). In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production (PubMed:24511121).SUBUNIT Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR (By similarity). Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB1. Binds PTK2B. Interacts with TRIM2 (By similarity).INTERACTION Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.PTM N-glycosylated.PTM Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Tyrosine-protein phosphatase non-receptor type substrate 1 shortName: SHP substrate 1 shortName: SHPS-1 alternativeName: Brain Ig-like molecule with tyrosine-based activation motifs shortName: Bit alternativeName: CD172 antigen-like family member A alternativeName: Inhibitory receptor SHPS-1 alternativeName: Macrophage fusion receptor alternativeName: MyD-1 antigen alternativeName: Signal-regulatory protein alpha-1 shortName: Sirp-alpha-1 alternativeName: Signal-regulatory protein alpha-2 shortName: Sirp-alpha-2 alternativeName: Signal-regulatory protein alpha-3 shortName: Sirp-alpha-3 alternativeName: p84 cdAntigenNameCD172a/cdAntigenName |
| geneName | SIRPA BIT MFR MYD1 PTPNS1 SHPS1 SIRP |
| identifier | P78324 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Disulfide bond Glycoprotein Immunoglobulin domain Membrane Phosphoprotein Proteomics identification Reference proteome Repeat SH3-binding Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SIRPA |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994509] ENSEMBL:ENSG00000198053 SIRPA [Homo sapiens] |
| secondaryIdentifier | SHPS1_HUMAN A2A2E1 A8K411 B2R6C3 O00683 O43799 Q8N517 Q8TAL8 Q9H0Z2 Q9UDX2 Q9UIJ6 Q9Y4U9 |
| sequenceLength | 504 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:101557] UniProt:P78324-1 SIRPA [Homo sapiens] [ReferenceIsoform:153865] UniProt:P78324-2 SIRPA [Homo sapiens] [ReferenceIsoform:8977204] UniProt:P78324-4 SIRPA [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:391102] p-Y429,Y453,Y470,Y496-SIRPA [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:3209922] SIRPA [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:6803288] SIRPA [tertiary granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:6803321] SIRPA [ficolin-1-rich granule membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:391100] O4'-phospho-L-tyrosine at 429 [ModifiedResidue:391101] O4'-phospho-L-tyrosine at 496 [ModifiedResidue:391104] O4'-phospho-L-tyrosine at 470 [ModifiedResidue:391105] O4'-phospho-L-tyrosine at 453 |
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No pathways have been reviewed or authored by UniProt:P78324 SIRPA (404821)
