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Details on Person UniProt:P61619 SEC61A1
| Class:Id | ReferenceGeneProduct:404605 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-476 added on Sat February 7 2015 |
| _displayName | UniProt:P61619 SEC61A1 |
| _timestamp | 2025-05-21 22:04:25 |
| chain | chain:1-476 |
| checksum | 44A9B7B37C7C82E4 |
| comment | FUNCTION Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:12475939, PubMed:22375059, PubMed:28782633, PubMed:29719251, PubMed:32814900). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:22375059, PubMed:28782633, PubMed:29719251). May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins (PubMed:22375059, PubMed:29719251). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:32820719, PubMed:36261522). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (PubMed:8616892). Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis (PubMed:28782633). Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity).SUBUNIT The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63 (PubMed:36697828). The SEC61 channel associates with the multi-pass translocon (MPT) complex (PubMed:32820719, PubMed:36261522).INTERACTION Localizes exclusively in granular structures in the endoplasmic reticulum (ER).ALTERNATIVE PRODUCTS Expressed in proximal and distal tubules in kidney (at protein level).DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the SecY/SEC61-alpha family. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Protein transport protein Sec61 subunit alpha isoform 1 shortName: Sec61 alpha-1 |
| geneName | SEC61A1 SEC61A |
| identifier | P61619 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Chaperone Disease variant Endoplasmic reticulum Membrane Protein transport Proteomics identification Reference proteome Translocation Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | SEC61A1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989203] ENSEMBL:ENSG00000058262 SEC61A1 [Homo sapiens] |
| secondaryIdentifier | S61A1_HUMAN P38378 P57726 Q5JPF8 Q8N0Z4 Q8N3U3 Q8NC71 Q9BU16 Q9Y2R3 |
| sequenceLength | 476 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:64052] UniProt:P61619-1 SEC61A1 [Homo sapiens] [ReferenceIsoform:247320] UniProt:P61619-3 SEC61A1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:444591] SEC61A1 [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:1236813] SEC61A1 [phagocytic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:5250557] SEC61A1 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P61619 SEC61A1 (404605)
