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Details on Person UniProt:P46952-1 HAAO
| Class:Id | ReferenceIsoform:404104 |
|---|---|
| _chainChangeLog | chain:1-286 added on Fri February 6 2015 |
| _displayName | UniProt:P46952-1 HAAO |
| _timestamp | 2024-11-03 19:34:46 |
| chain | chain:1-286 |
| checksum | 4DA6AC20FC6EC885 |
| comment | FUNCTION Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.CATALYTIC ACTIVITY 3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehydeCOFACTOR Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.SUBUNIT Monomer.INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the 3-HAO family. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: fullName evidence="1"3-hydroxyanthranilate 3,4-dioxygenase ecNumber evidence="1 4"1.13.11.6 alternativeName: fullName evidence="1"3-hydroxyanthranilate oxygenase shortName evidence="1"3-HAO shortName evidence="9"h3HAO alternativeName: fullName evidence="1"3-hydroxyanthranilic acid dioxygenase shortName evidence="1"HAD |
| geneName | HAAO |
| identifier | P46952 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm Dioxygenase Disease variant Iron Metal-binding Oxidoreductase Proteomics identification Pyridine nucleotide biosynthesis Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | HAAO |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001574] ENSEMBL:ENSG00000162882 HAAO [Homo sapiens] |
| secondaryIdentifier | 3HAO_HUMAN A6NE56 B4DIN2 Q53QZ7 Q8N6N9 |
| sequenceLength | 286 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P46952-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P46952-1 HAAO (404104)
