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Details on Person UniProt:P42226 STAT6
| Class:Id | ReferenceGeneProduct:404007 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-847 added on Sat February 7 2015;initiator methionine:1 for 404007 removed on Fri Nov 03 2023;initiator methionine: for 404007 added on Fri Nov 03 2023;initiator methionine: for 404007 removed on Fri Aug 15 2025;initiator methionine:1 for 404007 added on Fri Aug 15 2025 |
| _displayName | UniProt:P42226 STAT6 |
| _timestamp | 2025-08-15 22:04:36 |
| chain | initiator methionine:1 chain:2-847 |
| checksum | F35075F1C1F2A677 |
| comment | FUNCTION Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.SUBUNIT Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif.INTERACTION Translocated into the nucleus in response to phosphorylation.ALTERNATIVE PRODUCTS Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4 (PubMed:27796300). Tyrosine phosphorylated following stimulation by IL3/interleukin-3 (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling (PubMed:17210636).PTM Mono-ADP-ribosylated by PARP14.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the transcription factor STAT family. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Signal transducer and activator of transcription 6 alternativeName: IL-4 Stat |
| geneName | STAT6 |
| identifier | P42226 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Activator ADP-ribosylation Alternative splicing Cytoplasm Disease variant DNA-binding Nucleus Phosphoprotein Proteomics identification Reference proteome SH2 domain Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | STAT6 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003259] ENSEMBL:ENSG00000166888 STAT6 [Homo sapiens] |
| secondaryIdentifier | STAT6_HUMAN A8K316 B7ZA27 F5GXI9 Q5FBW5 Q71UP4 |
| sequenceLength | 847 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:65156] UniProt:P42226-1 STAT6 [Homo sapiens] [ReferenceIsoform:249649] UniProt:P42226-2 STAT6 [Homo sapiens] [ReferenceIsoform:8976263] UniProt:P42226-3 STAT6 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:629625] STAT6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:3249369] p-S407-STAT6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:3249376] p-S407,Y641-STAT6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:3261241] p-S407,Y641-STAT6 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6786109] p-Y641-STAT6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6786279] p-Y641-STAT6 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8983331] p-Y-STAT6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9007127] STAT6 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9007134] p-Y-STAT6 [nucleoplasm] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:3249387] O4'-phospho-L-tyrosine at 641 [ModifiedResidue:3249395] O-phospho-L-serine at 407 [ModifiedResidue:8983311] O4'-phospho-L-tyrosine at unknown position |
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No pathways have been reviewed or authored by UniProt:P42226 STAT6 (404007)
