Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P41134-1 ID1
| Class:Id | ReferenceIsoform:403964 |
|---|---|
| _chainChangeLog | chain:1-155 added on Fri February 6 2015 |
| _displayName | UniProt:P41134-1 ID1 |
| _timestamp | 2024-11-03 20:05:43 |
| chain | chain:1-155 |
| checksum | 480287384B667161 |
| comment | FUNCTION Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity).SUBUNIT Heterodimer with other HLH proteins. Interacts with COPS5, IFI204, GATA4 and NKX2-5 (By similarity). Interacts with CLOCK and BMAL1.INTERACTION Additional isoforms seem to exist.DEVELOPMENTAL STAGE Expression correlates with proliferation in some types of cells. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: DNA-binding protein inhibitor ID-1 alternativeName: Class B basic helix-loop-helix protein 24 shortName: bHLHb24 alternativeName: Inhibitor of DNA binding 1 alternativeName: Inhibitor of differentiation 1 |
| geneName | ID1 BHLHB24 ID |
| identifier | P41134 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Biological rhythms Cytoplasm Developmental protein Nucleus Proteomics identification Reference proteome Repressor Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ID1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993083] ENSEMBL:ENSG00000125968 ID1 [Homo sapiens] |
| secondaryIdentifier | ID1_HUMAN A8K537 E1P5L4 O00651 O00652 Q16371 Q16377 Q5TE66 Q5TE67 Q969Z7 Q9H0Z5 Q9H109 |
| sequenceLength | 155 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P41134-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P41134-1 ID1 (403964)
