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Details on Person UniProt:P26368-1 U2AF2
| Class:Id | ReferenceIsoform:403473 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-475 added on Fri February 6 2015;initiator methionine:1 for 403473 removed on Fri Nov 03 2023;initiator methionine: for 403473 added on Fri Nov 03 2023;initiator methionine: for 403473 removed on Fri Aug 15 2025;initiator methionine:1 for 403473 added on Fri Aug 15 2025 |
| _displayName | UniProt:P26368-1 U2AF2 |
| _timestamp | 2025-08-15 21:35:03 |
| chain | initiator methionine:1 chain:2-475 |
| checksum | 26AD271CD8FC6211 |
| comment | FUNCTION Plays a role in pre-mRNA splicing and 3'-end processing (PubMed:17024186). By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. Positively regulates pre-mRNA 3'-end processing by recruiting the CFIm complex to cleavage and polyadenylation signals (PubMed:17024186).SUBUNIT Interacts with U2AF1L4 (By similarity). Heterodimer with U2AF1 (PubMed:11551507). Binds unphosphorylated SF1 (PubMed:10449420, PubMed:12718882). Interacts with SCAF11 and SNW1 (PubMed:21460037, PubMed:9447963). Interacts with ZRSR2/U2AF1-RS2. Interacts with RBM17 (PubMed:17589525). Interacts with PRPF19; the interaction is direct. Interacts with POLR2A (via the C-terminal domain); recruits PRPF19 and the Prp19 complex to the pre-mRNA (PubMed:21536736). Interacts with KHDC4 (Isoform 2) (PubMed:19641227). Interacts with ZRSR2 (PubMed:9237760). Interacts with the SF3B complex composed of SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6 and PHF5A (PubMed:27720643). Interacts (via N-terminus) with CPSF7 (via C-terminus); this interaction stimulates pre-mRNA 3'-end processing by promoting the recruitment of the CFIm complex to cleavage and polyadenylation signals (PubMed:17024186). Interacts with ARGLU1; interaction may be involved in ARGLU1-mediated modulation of alternative splicing (PubMed:30698747).INTERACTION Lysyl-hydroxylation at Lys-15 and Lys-276 affects the mRNA splicing activity of the protein, leading to regulate some, but not all, alternative splicing events.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the splicing factor SR family. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Splicing factor U2AF 65 kDa subunit alternativeName: U2 auxiliary factor 65 kDa subunit shortName: hU2AF(65) shortName: hU2AF65 alternativeName: U2 snRNP auxiliary factor large subunit |
| geneName | U2AF2 U2AF65 |
| identifier | P26368 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Direct protein sequencing Disease variant Hydroxylation Intellectual disability Isopeptide bond mRNA processing mRNA splicing Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Repressor RNA-binding Spliceosome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | U2AF2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995770] ENSEMBL:ENSG00000063244 U2AF2 [Homo sapiens] |
| secondaryIdentifier | U2AF2_HUMAN Q96HC5 |
| sequenceLength | 475 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P26368-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P26368-1 U2AF2 (403473)
