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Details on Person UniProt:P23771-1 GATA3
| Class:Id | ReferenceIsoform:403390 |
|---|---|
| _chainChangeLog | chain:1-443 added on Fri February 6 2015 |
| _displayName | UniProt:P23771-1 GATA3 |
| _timestamp | 2024-11-03 19:41:02 |
| chain | chain:1-443 |
| checksum | F24C58681E1D02A5 |
| comment | FUNCTION Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages.SUBUNIT Interacts with TBX21 ('Tyr-530' phosphorylated form).INTERACTION T-cells and endothelial cells.DOMAIN Binds DNA via the 2 GATA-type zinc fingers. Each zinc finger may bind either adjacent sites in a palindromic motif, or a different DNA molecule allowing looping and long-range gene regulation.DOMAIN The YxKxHxxxRP motif is critical for DNA-binding and function.DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Trans-acting T-cell-specific transcription factor GATA-3 alternativeName: GATA-binding factor 3 |
| geneName | GATA3 |
| identifier | P23771 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Activator Alternative splicing Deafness Disease variant DNA-binding Immunity Innate immunity Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Transcription Transcription regulation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | GATA3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:6786289] ENSEMBL:ENSG00000107485 GATA3 [Homo sapiens] |
| secondaryIdentifier | GATA3_HUMAN Q5VWG7 Q5VWG8 Q96J16 |
| sequenceLength | 443 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P23771-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P23771-1 GATA3 (403390)
