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Details on Person UniProt:P23634 ATP2B4

Class:Id	ReferenceGeneProduct:403383
_chainChangeLog	chain:1-1241 added on Fri February 6 2015;chain:1-1241 removed on Fri May 8 2015;initiator methionine:1 added on Fri May 8 2015;chain:2-1241 added on Fri May 8 2015;initiator methionine:1 removed on Tue November 3 2015;chain:2-1241 removed on Tue November 3 2015;chain:1-1241 added on Tue November 3 2015
_displayName	UniProt:P23634 ATP2B4
_timestamp	2025-02-21 18:34:09
chain	chain:1-1241
checksum	568544103CD5F494
comment	FUNCTION Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity).CATALYTIC ACTIVITY Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)ACTIVITY REGULATION Activated by calcium/calmodulin.SUBUNIT Interacts with PDZD11 (PubMed:12763866). Interacts with SLC35G1 and STIM1 (PubMed:22084111). Interacts with calmodulin (PubMed:10493800, PubMed:2963820).INTERACTION There is a combination of two alternatively spliced domains at N-terminal site A (X and Z) and at C-terminal site B/C (A, B, D and K). The splice sites have mostly been studied independently. Full isoforms so far detected are isoform XA and isoform XB. Experimental confirmation may be lacking for some isoforms.TISSUE SPECIFICITY Isoform XB is the most abundant isoform and is expressed ubiquitously. Isoforms containing segment Z have only been detected in heart, while isoforms containing segment a have been found in heart, stomach and brain cortex.SIMILARITY Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
created	[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
description	recommendedName: fullName evidence="18"Plasma membrane calcium-transporting ATPase 4 shortName evidence="14 19"PMCA4 ecNumber evidence="13"7.2.2.10 alternativeName: Matrix-remodeling-associated protein 1 alternativeName: Plasma membrane calcium ATPase isoform 4 alternativeName: Plasma membrane calcium pump isoform 4
geneName	ATP2B4 ATP2B2 MXRA1
identifier	P23634
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing ATP-binding Calcium Calcium transport Calmodulin-binding Cell membrane Cell projection Cilium Direct protein sequencing Flagellum Ion transport Magnesium Membrane Metal-binding Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Translocase Transmembrane Transmembrane helix Transport
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	ATP2B4
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8990550] ENSEMBL:ENSG00000058668 ATP2B4 [Homo sapiens]
secondaryIdentifier	AT2B4_HUMAN B1APW5 B1APW6 Q13450 Q13452 Q13455 Q16817 Q7Z3S1
sequenceLength	1241
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:50455] UniProt:P23634-1 ATP2B4 [Homo sapiens] [ReferenceIsoform:144314] UniProt:P23634-2 ATP2B4 [Homo sapiens] [ReferenceIsoform:144315] UniProt:P23634-3 ATP2B4 [Homo sapiens] [ReferenceIsoform:144316] UniProt:P23634-4 ATP2B4 [Homo sapiens] [ReferenceIsoform:144317] UniProt:P23634-5 ATP2B4 [Homo sapiens] [ReferenceIsoform:144318] UniProt:P23634-6 ATP2B4 [Homo sapiens] [ReferenceIsoform:144319] UniProt:P23634-7 ATP2B4 [Homo sapiens] [ReferenceIsoform:144320] UniProt:P23634-8 ATP2B4 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:418304] ATP2B4 [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P23634 ATP2B4 (403383)