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Details on Person UniProt:P22891-1 PROZ
| Class:Id | ReferenceIsoform:403354 |
|---|---|
| _chainChangeLog | signal peptide:1-23 added on Sat February 7 2015;propeptide:24-40 added on Sat February 7 2015;chain:41-400 added on Sat February 7 2015 |
| _displayName | UniProt:P22891-1 PROZ |
| _timestamp | 2024-11-03 19:38:18 |
| chain | signal peptide:1-23 propeptide:24-40 chain:41-400 |
| checksum | 7EBD2DCC48860268 |
| comment | FUNCTION Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids.SUBUNIT Interacts with SERPINA10.INTERACTION Plasma.PTM The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.SIMILARITY Belongs to the peptidase S1 family.CAUTION Although related to peptidase S1 family vitamin K-dependent clotting factors, it has lost two of the essential catalytic residues and therefore lacks protease activity. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Vitamin K-dependent protein Z |
| geneName | PROZ |
| identifier | P22891 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Blood coagulation Calcium Cleavage on pair of basic residues Direct protein sequencing Disulfide bond EGF-like domain Gamma-carboxyglutamic acid Glycoprotein Hemostasis Hydroxylation Proteomics identification Reference proteome Repeat Secreted Serine protease homolog Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PROZ |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002566] ENSEMBL:ENSG00000126231 PROZ [Homo sapiens] |
| secondaryIdentifier | PROZ_HUMAN A6NMB4 Q15213 Q5JVF5 Q5JVF6 |
| sequenceLength | 400 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P22891-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P22891-1 PROZ (403354)
