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Details on Person UniProt:P22749-1 GNLY
| Class:Id | ReferenceIsoform:403348 |
|---|---|
| _chainChangeLog | signal peptide:1-22 added on Sat February 7 2015;chain:23-145 added on Sat February 7 2015 |
| _displayName | UniProt:P22749-1 GNLY |
| _timestamp | 2024-11-03 20:05:31 |
| chain | signal peptide:1-22 chain:23-145 |
| checksum | CEC5432FFBDBA1F4 |
| comment | FUNCTION Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.INTERACTION Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation.ALTERNATIVE PRODUCTS Expressed in natural killer and T-cells.INDUCTION By T-cell growth factor and IL2/interleukin-2.PTM A 9 kDa form is produced by proteolytic processing of a 15 kDa protein. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Granulysin alternativeName: Lymphokine LAG-2 alternativeName: Protein NKG5 alternativeName: T-cell activation protein 519 |
| geneName | GNLY LAG2 NKG5 TLA519 |
| identifier | P22749 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Antibiotic Antimicrobial Disulfide bond Fungicide Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | GNLY |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004710] ENSEMBL:ENSG00000115523 GNLY [Homo sapiens] |
| secondaryIdentifier | GNLY_HUMAN P09325 Q6GU08 |
| sequenceLength | 145 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P22749-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P22749-1 GNLY (403348)
