Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P20340-1 RAB6A
| Class:Id | ReferenceIsoform:403225 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-208 added on Fri February 6 2015;initiator methionine:1 for 403225 removed on Fri Nov 03 2023;initiator methionine: for 403225 added on Fri Nov 03 2023;initiator methionine: for 403225 removed on Fri Aug 15 2025;initiator methionine:1 for 403225 added on Fri Aug 15 2025 |
| _displayName | UniProt:P20340-1 RAB6A |
| _timestamp | 2025-08-15 21:48:16 |
| chain | initiator methionine:1 chain:2-208 |
| checksum | C9A3C2DDBF6C3E9E |
| comment | FUNCTION The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:25962623). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:25962623). RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed:25962623). Has a low GTPase activity (PubMed:25962623). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Plays a role in neuron projection development (Probable).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)COFACTOR Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity (Probable). Inhibited by GDP dissociation inhibitors (GDIs) (Probable).SUBUNIT Interacts (GTP-bound) with DYNLRB1; the interaction is direct (PubMed:18044744). Interacts with BICD1 (PubMed:12447383). Interacts with BICD2; the interaction is direct (PubMed:12447383, PubMed:20386726, PubMed:23664119, PubMed:25962623). Interacts (GTP-bound) with VPS13B (PubMed:25492866).SUBUNIT Interacts with BICD1 (PubMed:12447383). Interacts (GDP-bound) with DYNLRB1; the interaction is direct (PubMed:18044744). Interacts (GTP-bound) with VPS13B (PubMed:25492866).SUBUNIT Interacts with BICDL1; leads to its accumulation in the pericentrosomal region (By similarity). Interacts with SCYL1BP1 (PubMed:18997784). Interacts with VSP52 (PubMed:15878329). Interacts with RABGAP1 (PubMed:10202141). Interacts with GCC2 (via its GRIP domain) (PubMed:18243103). Interacts with RAB6IP1 (via its RUN 1 domain) (PubMed:19141279). Interacts with TMF1 (PubMed:17698061). Interacts with CIMAP3 (PubMed:20643351). Interacts (GTP-bound) with APBA1/MINT1 isoform 2, also called Mint1_826, but not with isoform 1 (PubMed:23737971). Interacts with RIC1; the interaction is direct with a preference for RAB6A-GDP (PubMed:23091056). Interacts with RGP1; the interaction is direct with a preference for RAB6A-GDP (PubMed:23091056).SUBUNIT (Microbial infection) Interacts with human cytomegalovirus protein UL32.INTERACTION BICD2 facilitates its targeting to Golgi apparatus membrane.SUBCELLULAR LOCATION Ubiquitous.DOMAIN Switch 1, switch 2 and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drives interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.PTM Prenylated.SIMILARITY Belongs to the small GTPase superfamily. Rab family. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Ras-related protein Rab-6A shortName: Rab-6 ecNumber evidence="8"3.6.5.2 |
| geneName | RAB6A RAB6 |
| identifier | P20340 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cytoplasmic vesicle Direct protein sequencing ER-Golgi transport Golgi apparatus GTP-binding Host-virus interaction Hydrolase Lipoprotein Membrane Methylation Nucleotide-binding Phosphoprotein Prenylation Protein transport Proteomics identification Reference proteome Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | RAB6A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995074] ENSEMBL:ENSG00000175582 RAB6A [Homo sapiens] |
| secondaryIdentifier | RAB6A_HUMAN A8K133 B7Z772 F5H668 Q1W5D8 Q5U0A8 Q9UBE4 |
| sequenceLength | 208 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P20340-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P20340-1 RAB6A (403225)
