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Details on Person UniProt:P18475-1 tor
| Class:Id | ReferenceIsoform:403152 |
|---|---|
| _chainChangeLog | signal peptide:1-20 added on Sat February 7 2015;chain:21-923 added on Sat February 7 2015 |
| _displayName | UniProt:P18475-1 tor |
| _timestamp | 2025-02-21 19:44:15 |
| chain | signal peptide:1-20 chain:21-923 |
| checksum | 746F46E1A4277ACF |
| comment | FUNCTION Probable receptor tyrosine kinase which is required for determination of anterior and posterior terminal structures in the embryo (PubMed:2927509, PubMed:8423783). During postembryonic development, involved in the initiation of metamorphosis probably by inducing the production of ecdysone in response to prothoracicotropic hormone Ptth (PubMed:19965758). Binding to Ptth stimulates activation of canonical MAPK signaling leading to ERK phosphorylation (By similarity).CATALYTIC ACTIVITY L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)COFACTOR Expressed both maternally and zygotically. Expressed throughout the embryo but is activated specifically at the poles (PubMed:19965758, PubMed:2927509, PubMed:8423783). Expressed in the prothoracic gland in wandering L3 larvae (PubMed:19965758).PTM May be auto-phosphorylated on tyrosine residues.DISRUPTION PHENOTYPE RNAi-mediated knockdown in the prothoracic gland (PG) delays the onset of pupariation by prolonging the L3 larval stage. In addition, pupal size and, to a lesser extent, PG cell size are increased.SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Tyrosine-protein kinase receptor torso ecNumber: 2.7.10.1 |
| geneName | tor CG1389 |
| identifier | P18475 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing ATP-binding Developmental protein Glycoprotein Kinase Magnesium Membrane Metal-binding Nucleotide-binding Phosphoprotein Receptor Reference proteome Signal Transferase Transmembrane Transmembrane helix Tyrosine-protein kinase |
| modified | [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | tor |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | TORSO_DROME A8DY54 A8DY56 Q9V4R2 |
| sequenceLength | 923 |
| species | [Species:56210] Drosophila melanogaster |
| variantIdentifier | P18475-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P18475-1 tor (403152)
