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Details on Person UniProt:P12314-1 FCGR1A
| Class:Id | ReferenceIsoform:402842 |
|---|---|
| _chainChangeLog | signal peptide:1-15 added on Sat February 7 2015;chain:16-374 added on Sat February 7 2015 |
| _displayName | UniProt:P12314-1 FCGR1A |
| _timestamp | 2026-02-20 21:29:59 |
| chain | signal peptide:1-15 chain:16-374 |
| checksum | D33D59398CEEA699 |
| comment | FUNCTION High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Mediates IgG effector functions on monocytes triggering antibody-dependent cellular cytotoxicity (ADCC) of virus-infected cells.SUBUNIT Interacts with the Fc region of IgG1, IgG2, IgG3 and IgG4 isotypes assembled in immune complexes (PubMed:11711607, PubMed:28566370, PubMed:25561553, PubMed:37421619). Interacts with FCERG1; forms a functional signaling complex. Interacts with FLNA; prevents FCGR1A degradation. Interacts with EPB41L2, LAT and PPL. Interacts with HCK and LYN.INTERACTION Stabilized at the cell membrane through interaction with FCER1G.ALTERNATIVE PRODUCTS Monocyte/macrophage specific.PTM Phosphorylated on serine residues.SIMILARITY Belongs to the immunoglobulin superfamily. FCGR1 family.ONLINE INFORMATION FCGR1A mutation db |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: High affinity immunoglobulin gamma Fc receptor I shortName: IgG Fc receptor I alternativeName: Fc-gamma RI shortName: FcRI alternativeName: Fc-gamma RIA shortName: FcgammaRIa cdAntigenNameCD64/cdAntigenName |
| geneName | FCGR1A FCG1 FCGR1 IGFR1 |
| identifier | P12314 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Direct protein sequencing Disulfide bond Glycoprotein IgG-binding protein Immunity Immunoglobulin domain Innate immunity Membrane Phosphoprotein Proteomics identification Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | FCGR1A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:5660066] ENSEMBL:ENSG00000150337 FCGR1A [Homo sapiens] |
| secondaryIdentifier | FCGR1_HUMAN P12315 Q5QNW7 Q92495 Q92663 |
| sequenceLength | 374 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P12314-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P12314-1 FCGR1A (402842)
