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Details on Person UniProt:P09496 CLTA
| Class:Id | ReferenceGeneProduct:402649 |
|---|---|
| _chainChangeLog | chain:1-248 added on Sat February 7 2015 |
| _displayName | UniProt:P09496 CLTA |
| _timestamp | 2024-11-03 20:18:25 |
| chain | chain:1-248 |
| checksum | 8D8A3B49E6353D93 |
| comment | FUNCTION Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582).SUBUNIT Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts with CALY; the interaction stimulates clathrin self-assembly and clathrin-mediated endocytosis. Interacts with CKAP5 and TACC3 forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges; the complex implicates clathrin triskelions.INTERACTION Cytoplasmic face of coated pits and vesicles. In complex with TACC3 and CKAP5 (forming the TACC3/ch-TOG/clathrin complex) localized to inter-microtubule bridges in mitotic spindles.ALTERNATIVE PRODUCTS Belongs to the clathrin light chain family. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Clathrin light chain A shortName: Lca |
| geneName | CLTA |
| identifier | P09496 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Calcium Cell cycle Cell division Coated pit Cytoplasm Cytoplasmic vesicle Cytoskeleton Membrane Mitosis Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CLTA |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992957] ENSEMBL:ENSG00000122705 CLTA [Homo sapiens] |
| secondaryIdentifier | CLCA_HUMAN A8K4W3 B4DIN1 F5H6N3 Q2XPN5 Q53XZ1 |
| sequenceLength | 248 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:52226] UniProt:P09496-1 CLTA [Homo sapiens] [ReferenceIsoform:145546] UniProt:P09496-2 CLTA [Homo sapiens] [ReferenceIsoform:224286] UniProt:P09496-3 CLTA [Homo sapiens] [ReferenceIsoform:8966502] UniProt:P09496-4 CLTA [Homo sapiens] [ReferenceIsoform:8966503] UniProt:P09496-5 CLTA [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:2980595] CLTA [lysosomal membrane] [Homo sapiens] [EntityWithAccessionedSequence:2980611] CLTA [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5138427] CLTA [clathrin-coated endocytic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:5333758] CLTA [trans-Golgi network membrane] [Homo sapiens] [EntityWithAccessionedSequence:8856817] CLTA [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8870825] CLTA [endolysosome membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P09496 CLTA (402649)
